Viral vaccines

Details Viral vaccines Viral vaccines

1993-06-23

1996-09-24

Fleisher, Mindy

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 9321, 4352351, 4353201, A61K 39255, C12N 701, C12N 1586

Patent

active

055588603

ABSTRACT:
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.

REFERENCES:
patent: 4895717 (1990-01-01), Witter
Gibbs et al., PNAS, v. 81, 1984, pp. 3365-3369.
Ono et al., Avian Diseases, v. 29, 1984, pp. 533-539.
Young et al., Science, v. 222, 1983, pp. 778-782.
Schat, Cancer Survey, v. 6, 1987, pp. 1-37.
K. Fukuchi et al., "Structure of Marek's Disease Virus DNA: Detailed Restriction Enzyme Map, " Journal of Virology, Jul. 1984, pp. 102-109.
I. Sithole et al., "Identification of Marek's Disease Herpes-Virus B Antigen's . . . ", 3rd Int'l Herpes Workshop, UC-Irvine, Aug. 7-13, 1988, pp. 221-222.

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