Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1993-06-23
1996-09-24
Fleisher, Mindy
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 9321, 4352351, 4353201, A61K 39255, C12N 701, C12N 1586
Patent
active
055588603
ABSTRACT:
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.
REFERENCES:
patent: 4895717 (1990-01-01), Witter
Gibbs et al., PNAS, v. 81, 1984, pp. 3365-3369.
Ono et al., Avian Diseases, v. 29, 1984, pp. 533-539.
Young et al., Science, v. 222, 1983, pp. 778-782.
Schat, Cancer Survey, v. 6, 1987, pp. 1-37.
K. Fukuchi et al., "Structure of Marek's Disease Virus DNA: Detailed Restriction Enzyme Map, " Journal of Virology, Jul. 1984, pp. 102-109.
I. Sithole et al., "Identification of Marek's Disease Herpes-Virus B Antigen's . . . ", 3rd Int'l Herpes Workshop, UC-Irvine, Aug. 7-13, 1988, pp. 221-222.
Binns Matthew M.
Ross Louis J. N.
Scott Simon D.
Fleisher Mindy
Ketter James
Rhone Merieux
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