Viral vaccines

Details Viral vaccines Viral vaccines

1995-06-05

1998-11-24

Ketter, James

Chemistry: molecular biology and microbiology

Vector, per se

536 2372, C12N 1585, C12N 1538

Patent

active

058405747

ABSTRACT:
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.

REFERENCES:
Buckmaster et al., "Gene Sequence and Mapping Data from Marek's Disease Virus and Herpesvirus of Turkeys: Implications for Herpesvirus Classification", J.gen.Virol. (1988) 69, 2033-2042.
Fukuchi et al., "Structure of Marek's Disease Virus DNA: Detailed Restriction Enzyme Map", Journal of Virology, Jul. 1984, pp. 102-109, vol. 51, No. 1.
Ono et al., "Partial Protection against Marek's Disease in Chickens Immunized with Glycoprotens gB Purified from Turkey-Herpesvirus-Infected Cells", Avian Diseases, vol. 29, No. 2, pp. 533-539.
Sithole et al., "Identification of Marek's Disease Herpes-Virus B Antigen Precursor Polypeptide and the Gene Encoding It", 13th International Herpes Workshop, California, Jul. 13, 1988, p. 221.
Brunovskis et al., "Identification of Genes Mapping in the Marek's Disease Herpesvirus Unique Short Region", 13th International Herpes Workshop, California, Jul. 13, 1988, p. 222.
Kato et al., "Advances in Marek's Disease Research", Proceedings of the 3rd International Symposium on Marek's Disease, Sep. 12-16, 1988.
Ikuta et al., "Immunoprecipitation of Marek's Disease Virus-Specific Polypeptides with Chicken Antibodies Purified by Affinity Chromatography", Virology 114, 227-281 (1981).
Igarashi et al., "Restriction Enzyme Map of Herpevirus of Turkey DNA and Its Collinear Relationship with Marek's Disease Virus DNA", Virology 157, 351-358 (1987).
Silva et al., "Monoclonal Antibody-Mediated Immunoprecipitation of Proteins from Cells Infected with Marek's Disease Virus or Turkey Herpes-Virus", Virology 136, 307-320 (1984).
Silva et al., Isolation and Partial Characterization of Three Glyco-proteins Common to Marek's Disease Virus and Turkey Herpesvirus-Infected Cells, pp. 101-110, Int'l Symposium on Marek's Disease, Ithaca, New York.
Gibbs et al., "Extensive Homology Exists Between Marek's Disease Herpesvirus and Its Vaccine Virus, Herpesvirus of Turkeys", Proc.Natl. Acad. Sci., vol. 81, pp. 365-3369, Jun. 1984.
Schat, Cancer Surveys, vol. 6, 1987, pp. 1-37.

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