Viral vaccines

Details Viral vaccines Viral vaccines

1998-12-30

2000-08-08

Ketter, James

Chemistry: molecular biology and microbiology

Vector, per se

4352351, 536 2372, C12N 1586

Patent

active

061000884

ABSTRACT:
A vaccine effective against Marek's disease virus (MDV) comprises (a) an MDV attenuated by virtue of being TK- or (b) a host expressing an MDV antigen, namely the respective MDV homologues of the HSV gB, gC, gD or gH glycoproteins (or antigenic parts thereof) or the respective MDV homologues of the HSV-1 immediate early genes IE-68 or IE-175. The host may be a herpes virus of turkeys (HVT), more particularly HVT in which the MDV antigen is inserted in the HVT homologue of the HSV gC gene, the ribonucleotide reductase (large subunit) gene or the thymidine kinase (TK) gene.

REFERENCES:
Nazerian et al., Avian Diseases, vol. 40, 1996, pp. 368-376, 1996.
Heine et al., Virus Research, vol. 50, 1997, pp. 23-33, 1997.

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