Viral sequences

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C435S325000

Reexamination Certificate

active

07125974

ABSTRACT:
An isolated nucleic acid comprising a nucleotide sequence at least 70% identical to SEQ ID NO:1, or a complementary sequence thereof. Presence of the nucleic acid in a subject predisposes the subject to an abnormal liver condition, an adenocarcinoma, or a combination thereof. Also disclosed are a method of diagnosing such diseases, a method of identifying a compound for treating such diseases, and a method of treating such diseases.

REFERENCES:
Hausen H, Oncogenic DNA viruses, 2001, Oncogene, vol. 20, pp. 7820-7823.
Scaglioni PP, Posttranscriptional regulation of hepatitis B virus replication by the precore protein, 1997, J. of Virology, vol. 71, pp. 345-353.
Elizabetta Bugianiesi et al. “Expanding the Natural History of Nonalcoholic Steatohepatitis: From Cryptogenic Cirrhosis to Hepatocellular Carcinoma”. Gastroenterology 123:134-140, 2002.
Jia-Horng Kao et al. “GB Virus-C/Hepatitis G Virus Infection in an Area Endemic for Viral Hepatitis, Chronic Liver Disease, and Liver Cancer”. Gastroenterology 112:1265-1270, 1997.
Akihiro Matsumoto et al. “Transfusion-Associated TT Virus Infection and Its Relationship to Liver Disease”. Heptology 30:283-288, 1999.
Fedja A. Rochling et al. “Acute Sporadic Non-A, Non-B, Non-C, Non-D, Non-E Hepatitis”. Hepatology 25:478-483, 1997.
Takeji Umemura et al. “SEN Virus: Response to Interferon Alfa and Influence on the Severity and Treatment Response of Coexistent Hepatitis C”. Hepatology 35:953-959, 2002.

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