Viral polymerase inhibitors

Details Viral polymerase inhibitors Viral polymerase inhibitors

2005-01-11

2005-01-11

Aulakh, Charanjit S. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S304700, C548S305100, C548S306100, C548S181000, C546S199000, C546S273400, C544S139000, C544S333000, C514S338000, C514S370000

Reexamination Certificate

active

06841566

ABSTRACT:
An isomer, enantiomer, diastereoisomer, or tautomer of a compound, represented by formula I:wherein R1is selected from: H, haloalkyl, (C1-6)alkyl, (C2-6)alkenyl, (C3-7)cycloalkyl, (C2-6)alkynyl, (C5-7)cycloalkenyl, 6 or 10-membered aryl, Het all optionally substituted;R2is selected from (C1-6)alkyl, (C3-7)cycloalkyl, (C6-10)bicycloalkyl, 6- or 10-membered aryl, or Het all optionally substituted;B is N or CR5, wherein R5is H, halogen, haloalkyl, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; X is N or CR5; D is N or CR5; each of Y1and Y2is independently O or S; Z is O, N, or NRZwherein RZis H, (C1-6)alkyl, (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; R3and R4are each independently H, (C1-6)alkyl, first (C3-7)cycloalkyl or 6- or 10-membered aryl, Het (C1-6)alkyl-6- or 10-membered aryl, (C1-6)alkyl-Het; or each R3and R4are independently covalently bonded together to form second (C3-7)cycloalkyl, or heterocycle, all optionally substituted; or when Z is N, either R3or R4are independently covalently bonded thereto to form a nitrogen-containing heterocycle; R7is H, (C1-6alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl; or R7is covalently bonded to either of R3or R4to form a heterocycle; A is (C1-6)alkyl-CONHR8wherein R8is -6- or 10-membered aryl, or Het; or A is a 6- or 10-membered aryl, or Het said aryl or Het being optionally substituted; or a salt or a derivative thereof; such compounds being potent inhibitors of HCV NS5B polymerase.

REFERENCES:
patent: 6448281 (2002-09-01), Beaulieu et al.
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patent: WO 0147883 (2001-07-01), None
Beaulieu, P. L. et al; “Viral Polymerase Inhibitors”; USSN 10/198,384; filed Jul. 18, 2002; attorney docket No. 13/090.
Beaulieu, P. L. et al; “Viral Polyerase Inhibitors”; USSN 10/198,680; filed Jul. 18, 2002; attorney docket No. 13/095.
Hashimoto, et al; “Fused-Ring Compounds And Use Thereof As Drugs”; Pub. No. US 2003/0050320 A1; Mar. 13, 2003.

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