Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-17
2009-08-18
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S339000, C514S340000, C514S370000, C544S133000, C548S181000
Reexamination Certificate
active
07576079
ABSTRACT:
An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I:wherein:A is O, S, NR1, or CR1, wherein R1is defined herein; represents either a single or a double bond;R2is selected from 6 or 10-membered aryl and Het, each optionally substituted with R20;provided that Het is not a 5- or 6-membered monocyclic heterocycle having 1 or 2 nitrogen heteroatoms;B is NR3or CR3, with the proviso that one of A or B is either CR1or CR3,wherein R3is defined herein;K is N or CR4, wherein R4is defined herein;L is N or CR5, wherein R5has the same definition as R4;M is N or CR7, wherein R7has the same definition as R4;Y1is O or S;Z is N(R6a)R6or OR6, wherein R6ais H or alkyl or NR61R62wherein R61and R62are defined herein; and R6is H, alkyl, cycloalkyl, alkenyl, Het, alkyl-aryl, alkyl-Het;or R6iswherein R7and R8and Q are as defined herein;Y2is O or S;R9is H, (C1-6alkyl), (C3-7)cycloalkyl or (C1-6)alkyl-(C3-7)cycloalkyl, aryl, Het, (C1-6)alkyl-aryl or (C1-6)alkyl-Het, all of which optionally substituted with R90; or R9is covalently bonded to either of R7or R8to form a 5- or 6-membered heterocycle;a salt or a derivative thereof, as an inhibitor of HCV NS5B polymerase.
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Beaulieu Pierre Louis
Fazal Gulrez
Gillard James
Goulet Sylvie
Kukolj George
Boehringer Ingelheim (Canada) Ltd.
Devlin Mary-Ellen M.
Dow David A.
Morris Michael P.
Saeed Kamal A
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