Viral polymerase inhibitors

Details Viral polymerase inhibitors Viral polymerase inhibitors

2011-03-01

2011-03-01

Habte, Kahsay T (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S351000, C546S268100, C546S300000

Reexamination Certificate

active

07897622

ABSTRACT:
Compounds of formula I:wherein X, R2, R3, R5and R6are defined herein, are useful as inhibitors of the hepatitis C virus NS5B polymerase.

REFERENCES:
patent: 7112600 (2006-09-01), Hashimoto et al.
patent: 2004/0082635 (2004-04-01), Hashimoto et al.
patent: 1 688 420 (2006-08-01), None
patent: 99/07733 (1999-02-01), None
patent: 99/07734 (1999-02-01), None
patent: 00/09543 (2000-02-01), None
patent: 00/09558 (2000-02-01), None
patent: 00/59929 (2000-10-01), None
patent: 01/47883 (2001-07-01), None
patent: 01/77113 (2001-10-01), None
patent: 01/81325 (2001-11-01), None
patent: 02/04425 (2002-01-01), None
patent: 02/08187 (2002-01-01), None
patent: 02/08198 (2002-01-01), None
patent: 02/08244 (2002-01-01), None
patent: 02/08256 (2002-01-01), None
patent: 02/48172 (2002-06-01), None
patent: 02/060926 (2002-08-01), None
patent: 03/000254 (2003-01-01), None
patent: 03/004458 (2003-01-01), None
patent: 03/007945 (2003-01-01), None
patent: 03/010140 (2003-02-01), None
patent: 03/010141 (2003-02-01), None
patent: 03/026587 (2003-04-01), None
patent: 03/053349 (2003-07-01), None
patent: 03/062228 (2003-07-01), None
patent: 03/062265 (2003-07-01), None
patent: 03/064416 (2003-08-01), None
patent: 03/064455 (2003-08-01), None
patent: 03/064456 (2003-08-01), None
patent: 03/093316 (2003-12-01), None
patent: 03/099274 (2003-12-01), None
patent: 03/101993 (2003-12-01), None
patent: 2004/030670 (2004-04-01), None
patent: 2004/032827 (2004-04-01), None
patent: 2004/037855 (2004-05-01), None
patent: 2004-039833 (2004-05-01), None
patent: 2004/043339 (2004-05-01), None
patent: 2004/064925 (2004-08-01), None
patent: 2004/065367 (2004-08-01), None
patent: 2004/072243 (2004-08-01), None
patent: 2004/087714 (2004-10-01), None
patent: 2004/093798 (2004-11-01), None
patent: 2004/094452 (2004-11-01), None
patent: 2004/101602 (2004-11-01), None
patent: 2004/101605 (2004-11-01), None
patent: 2004/103996 (2004-12-01), None
patent: 2004/113365 (2004-12-01), None
patent: 2005/010029 (2005-02-01), None
patent: 2005/014543 (2005-02-01), None
patent: 2205/012288 (2005-02-01), None
patent: 2005/021584 (2005-03-01), None
patent: 2005/028501 (2005-03-01), None
patent: 2005/030796 (2005-04-01), None
patent: 2005/037214 (2005-04-01), None
patent: 2005/046712 (2005-05-01), None
patent: 2005/049622 (2005-06-01), None
patent: 2005/051410 (2005-06-01), None
patent: 2005/051980 (2005-06-01), None
patent: 2005/054430 (2005-06-01), None
patent: 2005/058821 (2005-06-01), None
patent: 2005/070955 (2005-08-01), None
patent: 2005/080388 (2005-09-01), None
patent: 2005/085197 (2005-09-01), None
patent: 2005/085242 (2005-09-01), None
patent: 2005/085275 (2005-09-01), None
patent: 2005/087721 (2005-09-01), None
patent: 2005/087725 (2005-09-01), None
patent: 2005/087730 (2005-09-01), None
patent: 2005/087731 (2005-09-01), None
patent: 2005/107745 (2005-11-01), None
patent: 2005/113581 (2005-12-01), None
patent: 2005/121132 (2005-12-01), None
patent: 2006/000085 (2006-01-01), None
patent: 2006/007693 (2006-01-01), None
patent: 2006/007700 (2006-01-01), None
patent: 2006/007708 (2006-01-01), None
A.F. Abdel-Magid, et al., “Reductive Amination of Aldehydes and Ketones with Sodium Triacetoxyborohydride. Studies on Direct and Indirect Reductive Amination Procedures”, J. Org. Chem., 1996, vol. 61, p. 3849.
S. M. Berge, et al., “Pharmaceutical Salts”, Journal of Pharmaceutical Sciences, 1977, vol. 66, No. 1, p. 1.
E. Buck, et al., “Preparation of 1-Methoxy-2-(4-Methoxyphenoxy) Benzene”, Org. Syntheses, 2005, vol. 82, p. 69.
R. Hemalatha, et al., “QSAR Analysis of 5-substituted-2-Benzoylaminobenzoic acids as PPAR Modulator”, E-Journal of Chemistry, 2004, vol. 1, No. 5, p. 243-250S.
E. J. Hennessy, et al., “A General and Mild Copper-Catalyzed Arylation of Diethyl Malonate”, Organic Letters, 2002, vol. 4, No. 2, p. 269.
A. A. Kolykhalov, et al., “Hepatitis C Virus-Encoded Enzymatic Activities and Conserved RNA Elements in the 3′ Nontranslated Region are Essential for Virus Replication in Vivo”, J. Virology, 2000, vol. 74, No. 4, p. 2046.
G. McKercher, et al., “Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate”, Nucleic Acids Res., 2004, vol. 32, No. 2, p. 422.
T. Östberg, et al., “A New Class of Peroxisome Proliferator-activated Receptor Agonists with a novel Binding Epitope Shows Antidiabetic Effects”, J. Biological Chemistry, 2004, vol. 279, No. 39, p. 41124.
W. C. Still, et al., “Rapid Chromatographic Technique for Preparative Separations with Moderate Resolution”, J. Org. Chem., 1978, vol. 43, No. 14, p. 2923.
K. Takagi, “Synthesis of Aromatic Thiols from Aryl Iodides and Thiourea by Means of Nickel Catalyst”, Chemistry Letters, 1985, p. 1307.
K. Tanaka, et al., “Synthesis and Reaction of 5-Amino-3-trifluoromethylisoxazole and—pyrazole-4-carboxylic Acids”, J. Heterocyclic Chem., 1986, vol. 23, p. 1535.
M. Thor, et al., “Synthesis and Pharmacological Evaluation of a New Class of Peroxisome Proliferator-Activated Receptor Modulators”, Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, p. 3565.
International Search Report PCT/CA2007/001363, Mailed Oct. 29, 2007.

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