Viral particles with exogenous internal epitopes

Details Viral particles with exogenous internal epitopes Viral particles with exogenous internal epitopes

2006-11-14

2006-11-14

Stucker, Jeffrey (Department: 1648)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

C435S235100, C435S235100, C435S320100, C530S806000, C530S826000, C424S184100

Reexamination Certificate

active

07135282

ABSTRACT:
The present invention relates to the expression of peptides on viral particles, and more particularly to the expression of peptides on the interior or the viral capsid. Methods are described for modifying viruses so that exogenous epitopes are expressed on the interior of the viral capsid. Viruses that can be modified include (+) stranded RNA viruses, especially plant (+) stranded RNA viruses such as the cowpea mosaic virus. Internal expression is especially useful for the expression of hydrophobic epitopes. The modified viral particles also find use as vaccines and as such are capable of eliciting an immune response.

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