Viral oncolysate vaccine for stimulating the immune mechanism of

Details Viral oncolysate vaccine for stimulating the immune mechanism of Viral oncolysate vaccine for stimulating the immune mechanism of

1976-06-01

1978-08-22

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

195 18, A61K 3912, C12K 900

Patent

active

041089839

ABSTRACT:
A virus-lysed tumor cell vaccine is an active immunotherapeutic agent against tumors in mammals. In particular, a vaccine based upon vaccinia virus-lysed, species-specific tumor cells is an effective stimulator of the immune response in mammals, and a vaccine based upon vaccinia virus-lysed spontaneously arising tumor cells is an effective stimulator of the immune response in some human cancer patients. A process for preparing the vaccine by viral oncolysis is also disclosed. Tumor cells are removed from a mammal, the cells are cultured in a culture medium and infected with live vaccinia virus. Viral oncolysis occurs during incubation and the resulting viral oncolysate, after extraction, may be injected into mammals to stimulate the immune response mechanism.

REFERENCES:
patent: 3553312 (1971-01-01), Delgado

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