Viral nucleotide sequences

Details Viral nucleotide sequences Viral nucleotide sequences

1993-09-22

1999-05-25

Guzo, David

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424 932, 424 936, 4352351, 4353201, A61K 39255, A61K 4800, C12N 701, C12N 1586

Patent

active

059068213

ABSTRACT:
Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.

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