Viral isolates and their use in diagnosis

Details Viral isolates and their use in diagnosis Viral isolates and their use in diagnosis

1988-04-05

1990-03-27

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

424 89, 424 93, 435 7, 435 93, 435188, 435235, 435810, 436518, 436531, 436543, 436547, 436804, 436808, 436809, 436810, 436815, 436820, 436823, G01N 33569

Patent

active

049120301

ABSTRACT:
Samples e.g. transfusion blood, are assayed for antibodies to retroviruses, e.g. AIDS virus, using an insolubilized antigen comprising retrovirus antigens bound to globulin, the globulin itself being bound to an inert solid support; and an immunoglobulin which contains specific antibody to the retrovirus antigens and which is labelled with a revealing label, and the soluble phase is then separated from the insoluble phase and the quantity of revealing label associated with either the soluble or the insoluble phase determined.
The sue of labelled antibody in competition with test sera for binding on the insolublized antigen permits better identification of antibody containing specimens. The retroviruses may be a human T-lymphotropic retrovirus HTLV-I, II or III or a new retrovirus isolate CBL-1 etiologically related to AIDS.

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