Viral inactivation method using near critical, supercritical or

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits

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435 2, 4352861, A01N 102, C12N 706, C12M 302

Patent

active

058770054

ABSTRACT:
The invention involves the use of supercritical or near-critical fluids for the inactivation of viruses, especially enveloped or lipid protected viruses, and nonenveloped, protein encased viruses, viral-like particles and other pathogens in any matrix, but preferably in solutions containing biologically active proteinaceous products of natural or genetic engineering origin or in semi-solid or solid support matrices which are thermally labile or sensitive to conventional viral inactivation techniques. Novel apparatus also are provided.

REFERENCES:
patent: Re32695 (1988-06-01), Nahra et al.
patent: 4749522 (1988-06-01), Kamarei
patent: 5520943 (1996-05-01), Osajima et al.
patent: 5667835 (1997-09-01), Osajima et al.

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