Viral (HIV) growth inhibition

Details Viral (HIV) growth inhibition Viral (HIV) growth inhibition

1998-05-22

2000-09-05

Yucel, Remy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

435 6, 536 231, C12Q 100

Patent

active

061141097

ABSTRACT:
A synthetic molecule comprises at least one oligonucleotide, comprising and RNA binding sequence or sequences corresponding to the site bound by the HIV protein tat and capable of binding to tat within cells. The binding sequence or sequences, by binding tat within cells, can act to cause inhibition of growth of any HIV present in the cells, and so has potential therapeutic use in treatment of patients affected with HIV. The invention also provides an assay for identifying compounds that inhibit tat binding.

REFERENCES:
patent: 5821046 (1998-10-01), Karn et al.
Dingwall et al., Proc. Natl. Acad. Sci. USA 86:6925-6929 (1989).

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