Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1991-04-24
1993-01-12
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424490, 424493, 424 88, 424 89, 514934, 514 2, A61K 916, A61K 3912
Patent
active
051788829
ABSTRACT:
A biologically active composition made up of core particles having diameters of less than about 1000 nanometers which are coated with a layer which is designed to allow attachment of biologically active proteins, peptides or pharmacological agents to the microparticles. When viral protein is attached to the core particles, the result is a viral decoy which accurately mimics the native virus in both size and structure while being entirely devoid of virulent activity due to the microparticle core. Other antigenic proteins or peptides are attached to provide molecules which are useful in raising antibodies or as a diagnostic tool. Further, pharmacological agents are attached to the microparticles to provide pharmaceutical compositions. The viral decoys are useful as vaccines for treating animals to elicit an immune response.
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Kubiak, C., Couvreur, P., Manil, L., Clausse , B., "Increased Cytotoxicity of Nanoparticles Carried Adriamycin in Vitro and Potentiation by Verapamil and Amiodarone", Biomaterials 1989, vol. 10 Oct. pp. 553-556.
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Bunshah Rointan F.
Kossovsky Nir
Page Thurman K.
Spear James M.
The Regents of the University of California
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