Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1997-10-14
2000-08-01
Saunders, David
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
4241731, 4241761, 5303896, 530414, A61K 39395, C07K 1634
Patent
active
060968729
ABSTRACT:
Methods for producing immunoglobulins and in particular anti-D immunoglobulin substantially free of virus and product resulting therefrom. Specifically provided are methods for nanofiltration of the anti-D immunoglobulin in high ionic strength buffer and with excipient such as polysorbate 80. Additional steps include diafiltration to concentrate the anti-D protein and reduce the concentration of excipient present.
REFERENCES:
patent: 3449314 (1969-06-01), Pollack
patent: 3916026 (1975-10-01), Stephan
patent: 4021540 (1977-05-01), Pollack et al.
patent: 4141887 (1979-02-01), Seufert
patent: 4590002 (1986-05-01), Zolton et al.
patent: 4880913 (1989-11-01), Doleschel et al.
patent: 5115101 (1992-05-01), Bloom et al.
patent: 5215681 (1993-06-01), Truong et al.
patent: 5723123 (1998-03-01), Karges et al.
Van Holten, R.W. et al. Incorporation of a viral clearance step into a modified Cohn fractionation. Transfusion 35:13S, Oct. 1995.
Dorland's Illustrated Medical Dictionary, 28th Edition. W.B. Saunders Co. Philadelphia, 1994.
Hardy, R.R. Purification and characterization of monoclonal antibodies. Chapter 13 in Handbook of Experimental Immunology In Four Volumes. D.M. Weir, Editor. Blackwell Scientific Publications. Oxford. pp.13.1-13.13.
Ortho Diagnostic Systems Inc. MICRhoGAM TM and RhoGAM TM. in Physicians' Desk Reference. Medical Economics Data Production Co. Montvale, NJ. pp.1770-1771, 1995.
"Value of Virus Filtration as a Method for Improving the Safety of Plasma Products", Vox Sang 1995; 69:82-83.
"Size Exclusion Removal of Model Mammalian Viruses Using a Unique Membrane System, Part I: Membrane Qualification", Biologicals (1993) 21, 275-286.
"Removal of Causative Agent of Creutzfeldt-Jakob Disease (CJD) Through Membrane Filtration Method", Membrane, 18(6), 357-362 (1993).
"Preparation and Properties of Serum and Plasma Proteins. IV. A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids", 1949, J. Am Chem. Soc. 68:459-475.
"Value of Virus Filtration as a Method for Improving the Safety of Plasmaa Products", Vox Sang, 1996; 70:235-236.
"The Separation of the Antibodies, Isoagglutinins, Prothrombin, Plasminogen and .beta..sub.1 --Lipoprotein into Subfractions of Human Plasma", Subfractions of Human Plasma, Feb. 1949 vol. 71, pp. 541-550.
Oulundsen, Jr. George E.
Quinton Gilbert J.
Van Holten Robert William
Millipore Corporation
Ortho Diagnostic Systems Inc.
Saunders David
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