Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1998-07-22
2000-03-14
Mosher, Mary E.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
250282, C12Q 170, G01N 128, G01N 3700
Patent
active
060371188
ABSTRACT:
The present invention provides a method of direct detecting of capsid proteins from intact viral particles using matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry, which enables viral proteins to be characterized at the femtomolar level in complex biological milieu with minimal or no cleanup.
REFERENCES:
Siuzdak, G. Journal of Mass Spectrometry 33:203-211, 1998.
Krishnamurthy et al. Journal of Natural Toxins 6:121-162, Jun. 1997.
Fenselau Catherine
Thomas John J.
Adler Benjamin Aaron
Mosher Mary E.
University of Maryland Baltimore County
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