Viral CD30 polypeptide

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing

Reexamination Certificate

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Details

C424S185100, C424S186100, C424S232100

Reexamination Certificate

active

10503687

ABSTRACT:
The present invention relates to the identification and characterisation of a viral homologue (vCD30) of mammalian CD30. The vCD30 polypeptide is shown to have immunomodulatory activity and has various therapeutic applications.

REFERENCES:
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Chen et al., “Analysis of host response modifier ORFs of ectromelia virus, the causative agent of mousepox,”Virus Research, 66:155-173 (2000).
Panus et al., “Coxpox virus encodes a fifth member of the tumor necrosis factor receptor family: A soluable, secreted CD30 homologue,”PNAS, 99(12):8348-8353 (2002).
Saraiva et al., “CrmE, a Novel Soluable Tumor Necrosis Factor Receptor Encoded by Poxviruses,”Journal of Virology, 75(1):226-233 (2001).
Shchelkunov et al., “The Genomic Sequence Analysis of the Left and Right Species-Specific Terminal Region of a Cowpox Virus Strain Reveals Unique Sequences and a Cluster of Intact ORFs for Immunomodulatory and Host Range Proteins,”Virology, 243:432-260 (1998).
Database EMBL ‘Online’, D13 L protein,EBI Database accessionNo. P87599, XP002248019, May 1, 1997.

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