Viral and insect genes that inhibit the immune system and method

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4241991, 4242041, 424 932, 424 936, 4353201, 536 2372, A61K 3912, C12N 1586

Patent

active

058275185

ABSTRACT:
Viral, endoparasitoid and/or host genes that specifically inhibit the immune response of insect pests, useful for broadening the host range of insect viruses. Symbiont viruses of insect pests are genetically modified to express immune-suppressing proteins or biologically active fragments thereof and, optionally toxins, to increase the virus host range and/or improve the efficacy of insect pathogens.

REFERENCES:
Webb and Luckhart, "Evidence of an Early Immunosuppresive Role for Related Campoletis Sonorensis Venom and Ovarian Proteins in Heliothis Virescens", Jun. 14, 1993, pp. 147-163, Department of Entomology, New Brunswick, NJ.
Schmidt et al., "Role of Virus-like Particles in Parasitoid-Host Interaction of Insects", Subcell. Biochem., 15:91 (1989), Institute for Biology III, Germany.
Davies et al., "Interference with function of plasmatocytes of Heliothis Virescens in vivo by calyx fluid of the parasitoid Campoletis sonorensis", 1988, pp. 467-475, Department of Entomology, College Station, Texas.
Hayakawa, "Cellular Immunosuppressive Protein in the Plasma of Parasitized Insect Larvae", May 20, 1994, pp. 14536-14540, The American Society for Biochemistry and Molecular Biology, Inc..
S. Bradleigh Vinson, "How Parasitoids Deal With the Immune System of Their Host: An Overview", Sep. 23, 1989, pp. 3-27, Department of Entomology, College Station, Texas.
Summers et al., "Polydnavirus-facilitated endoparasite protection against host immune defenses", Jan. 1995, pp. 29-36, Department of Entomology, College Station, Texas.
Li et al., "Apparent Functional Role for a Cysteine-Rich Polydnavirus Protein in Suppression of the Insect Cellular Immune Response", Aug. 4, 1994, Department of Entomology, New Brunswick, NJ.
Krell et al., "Virus with a Multipartite Superhielical DNA Genome from the Ichneumonid Parasitoid Campoletis sonorensis", May 27, 1982, Department of Entomology, College Station, Texas.
Dib-Hajj et al., "Structure and evolutionary implications of a cysteine-rich Campoletis sonorensis polydnavirus gene family", Jan. 26, 1993, Department of Entomology, Texas and New Jersey.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Viral and insect genes that inhibit the immune system and method does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Viral and insect genes that inhibit the immune system and method, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Viral and insect genes that inhibit the immune system and method will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1612020

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.