Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1996-03-27
1998-10-27
Guzo, David
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4241991, 4242041, 424 932, 424 936, 4353201, 536 2372, A61K 3912, C12N 1586
Patent
active
058275185
ABSTRACT:
Viral, endoparasitoid and/or host genes that specifically inhibit the immune response of insect pests, useful for broadening the host range of insect viruses. Symbiont viruses of insect pests are genetically modified to express immune-suppressing proteins or biologically active fragments thereof and, optionally toxins, to increase the virus host range and/or improve the efficacy of insect pathogens.
REFERENCES:
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Schmidt et al., "Role of Virus-like Particles in Parasitoid-Host Interaction of Insects", Subcell. Biochem., 15:91 (1989), Institute for Biology III, Germany.
Davies et al., "Interference with function of plasmatocytes of Heliothis Virescens in vivo by calyx fluid of the parasitoid Campoletis sonorensis", 1988, pp. 467-475, Department of Entomology, College Station, Texas.
Hayakawa, "Cellular Immunosuppressive Protein in the Plasma of Parasitized Insect Larvae", May 20, 1994, pp. 14536-14540, The American Society for Biochemistry and Molecular Biology, Inc..
S. Bradleigh Vinson, "How Parasitoids Deal With the Immune System of Their Host: An Overview", Sep. 23, 1989, pp. 3-27, Department of Entomology, College Station, Texas.
Summers et al., "Polydnavirus-facilitated endoparasite protection against host immune defenses", Jan. 1995, pp. 29-36, Department of Entomology, College Station, Texas.
Li et al., "Apparent Functional Role for a Cysteine-Rich Polydnavirus Protein in Suppression of the Insect Cellular Immune Response", Aug. 4, 1994, Department of Entomology, New Brunswick, NJ.
Krell et al., "Virus with a Multipartite Superhielical DNA Genome from the Ichneumonid Parasitoid Campoletis sonorensis", May 27, 1982, Department of Entomology, College Station, Texas.
Dib-Hajj et al., "Structure and evolutionary implications of a cysteine-rich Campoletis sonorensis polydnavirus gene family", Jan. 26, 1993, Department of Entomology, Texas and New Jersey.
Cui Liwang
Webb Bruce Allen
Guzo David
University of Kentucky Research Foundation
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