Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1994-09-07
1995-11-14
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424DIG15, 514967, 435853, 435854, A61F 1320, A61F 608, C12N 1104
Patent
active
054664632
ABSTRACT:
A vaginal suppository or other type of vaginal pessary such as cream, foam or ointment, which contains as its active ingredients at least one pharmaceutically acceptable, topically safe antimicrobial agent, such as an agent selected from the group of benzalkonium chloride, cetylpyridinium chloride, chlorhexidine gluconate and povidone iodine, imidiazolidinyl urea and diazolidinyl urea and a viable colony of micro-encapsulated lactobacilli bacteria. The viable lactobacilli are included in the suppository in micro encapsulated form, which protects the bacteria during storage of the suppository from the action of the bacteriocidal agent. When exposed to the vaginal milieu the micro encapsulation breaks down sufficiently to release the lactobacili bacteria. The lactobacilli bacteria serve to maintain or re-establish a healthy lactobacilli based flora on the vaginal wall, and excrete hydrogen peroxide and other bactericidins which suppress abnormal flora conditions that promote infections.
REFERENCES:
patent: 4579734 (1986-04-01), Hata et al.
patent: 4983163 (1991-01-01), Winans, Jr. et al.
Monif, Gilles R. G. et al. "Quantitative and qulitative effects of povidone-iodine liquid and gel on the aerobic and anaerobic flora of the female genital tract", Am.J. Obstet. Gynecol. 137(4): 432-438 (Jun. 15, 1980).
McGroarty, Jacqueline A. et al. "Development of Lactobacillus Probiotics", Clinical Advances in the Treatment of Infections, New York, pp. 16, 13-14.
McGroarty, Jacqueline A. and Moody, Karen J., "nonoxynol-9 and Urogenital Infections in Women", Clinical Advances in the Treatment of Infections, p. 16, 12-14.
Sherris, Jacqueline D. et al. "New Developments in Vaginal Contraception", Population Reports, (By Population Information Program, The Johns Hopkins University), 12(1): H-159-191 (1984).
McGroarty, Jacqueline A. et al. "Influence of the spermicidal compound Nonoxynol-9 on the growth and Adhesion of Urogenital bacteria in vitro", Current Microbiology, vol. 21 (1990), 219-223.
McGroarty, Jacqueline A. et al. "Hydrogen Peroxide Production by Lactobaillus Species: Correlation with Susceptibility to the Spermicidal Compound Nonoxyno-9", JID, 1992:165 (Jun.), 1142-1144.
McGroarty, J. A. et al. "Influence of the Spermicidal Compound Nonoxynol-9 on the Adhesion of E coli to Human Epithelial Cells", Int Urogynecol J, (1993)4: 194-198.
McGroarty, J. A. et al. "Modulation of Adhesion of Uropathogenic Enterococcus faecalis to Human Epithelia Cells in vitro by Lactobacillus species", Microbial Ecology in Health and Disease, vol. 5: 309-314(1992).
McGroarty, Jacqueline A. et al. "The Spermicidal Compound Nonoxynol-9 Increases Adhesion of Candida Species to Human Epithelial Cells in Vitro", Infection and Immunity, 58(6): pp. 2005-2007, (Jun., 1990).
Kreiss, Joan et al. "Efficacy of Nonoxynol 9 Contraceptive Sponge Use in Preventing Heterosexual Acquisition of HIV in Nairobi Prostitutes", JAMA, Jul. 22/29, 1992, 268(4): 447-482.
Goldin, Barry R. and Gorbach, Sherwood L. "Alterations of the Intestinal Microflora by Diet, Oral Antibiotics, and Lactobacillus: Decreased Production of Free Amines From Aromatic Nitro Compounds, Azo Dyes, and Glucuronides", JNCI, 73(3): 689-695(Sep. 1984).
Barefoot, Susan F. and Klaenhammer, Todd R. "Detection and Activity of Lactacin B, a Bacteriocin Produced by Lactosbacillus acidophilus", Applied and Environmental Microbiology, 45(6):1808-1815(Jun., 1983).
Barefoot, Susan F. and Klaenhammer, Todd R. "Purification and Characterization of the Lactobacillus acidophilus Bacteriocin Lactacin B", Antimicrobial Agents and Chemotherapy, 26(3): pp. 328-334 (Sep. 1984).
Mehta, A. M. et al. "Purification and properties of the inhibitory protein isolated from Lactobacillus acidophilus AC", Microbios, 38: pp. 73-81(1983).
Silva, M. et al. "Antimicrobial Substance from a Human Lactobacillus Strain", Antimicrobial Agents and Chemotherapy, 31(8): pp. 1231-1233(Aug. 1987).
S. Leodolter, E. Reinhold et al. "Ceftriaxon, I g i.v.-Effectively Prevents Infections and Is Cost Effective", Program And Abstras-3rd World Congress for Infectious Diseases in Obstetrics and Gynecology combined with Infectious Diseases in Urology, Dermatology, and Clinical Immunology, Acapulco, Mex., 1993. p. 110.
Ford, L. C. et al. "In Vitro Antimicrobial Effects of the Inner Confidence Lactobacilli (Lactobacillus Acidophilus 6 Lactobacillus Rhamnosus)" Program And Abstrats-3rd World Congress for Infectious Diseases in Obstretrics and Gynecology combined with Infectious Diseases in Urology, Dermatology and Clinical Immunology, Acapulco, Mex., 1993, p. 110.
Ford, L. C. et al. "Safety of Inner Confidence Supporitories", Proram And Abstracts-3rd World Congress for Infectious Diseases in Obstetrics and Gynecology combined with Infectious Diseases in Urology, Dermatology and Clinical Immunology, Acapulco, Mex., 1993, p. 111.
Ford, L. C. et al. "Topical Therapy of Bacterial Vaginosis", Program and Abstracts-1st World Congress for Infectious Diseases in Obstetrics and Gynecology, Hawaii, USA, 1989, p. 78.
Azpuru Carlos A.
Lafor Laboratories Limited
LandOfFree
Viracidal, bactericidal and spermicidal vaginal suppository does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Viracidal, bactericidal and spermicidal vaginal suppository, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Viracidal, bactericidal and spermicidal vaginal suppository will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1219299