Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1985-10-31
1988-04-12
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 16, 530327, 530328, A61K 3702, C07K 706
Patent
active
047374870
ABSTRACT:
Peptides comprising, in sequence, units selected from the amino acid residues 11 to 23 of vasoactive intestinal peptide (VIP) and consisting at least of the amino acid residues 15 to 20, or an analogue thereof wherein one or more of the amino acid residues is replaced by an equivalent other amino acid, or a pharmaceutically acceptable salt thereof; having pharmacological activity, a process for their preparation and their use as pharmaceuticals.
REFERENCES:
patent: 3862927 (1975-01-01), Said et al.
patent: 3898329 (1975-08-01), Said et al.
patent: 4016258 (1977-04-01), Said et al.
patent: 4237046 (1980-12-01), Bodanszky
patent: 4605641 (1986-08-01), Bolin et al.
A. Couvineau et al., "Structural Requirements for VIP Interaction with Specific Receptors in Human and Rat Intestinal Membranes: Effect of Nine Partial Sequences", Biochemical and Biophysical Research Communications, 121, pp. 493-498 (1984).
M. Bodanszky et al., "A Preferred Conformation in the Vasoactive Intestinal Peptide (VIP), Molecular Architecture of Intestinal Hormones", Bioorganic Chemistry, 3, pp. 133-140 (1974).
H. C. Beyerman et al., "Synthesis, Biological & Immunological Properties of Analogs of Secretin and Vasoactive Intestinak Peptide (VIP): the Vasectrins", Chem. Abs., vol. 95, p. 230 (1981): Life Sci., 29(9), pp. 895-902 (1981).
M. Bodanszky et al., "Vasoactive Intestinal Peptide (VIP). VI. 17--Norleucine Analog of the Sequence 14-28", Chem. Abs., vol. 82, p. 57 (1975): Bioorg. Chem., 3(3), pp. 320-323 (1974).
G. Wendlberger et al., "Total Synthesis of the 17--Norleucine Analog of Porcine Vasoactive Intestinal Polypeptide (VIP), Chem. Abs., vol. 98, p. 544 (1983): Pept. Proc. Eur. Pept. Symp., 16th, pp. 209-295 (Pub. 1981).
Summers Christine
Watts Eric A.
Wootton Gordon
Beecham Group p.l.c.
Haley, Jr. James F.
Phillips Delbert R.
Solomon Teresa L.
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