Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing
Patent
1993-11-16
1995-05-09
Richter, Johann
Organic compounds -- part of the class 532-570 series
Organic compounds
Sulfur containing
568 30, 568 31, 568 32, 568 33, C07C31504, C07C31704
Patent
active
054141354
ABSTRACT:
A new class of polyalkylene oxide vinyl sulfone reagents is described. Also described are a method by which these reagents can be prepared as well as a method for using them in hydrated media for the modification of proteins. The novel polymer-to-protein conjugates made by reacting these reagents with proteins have advantages over similar conjugates prepared with prior art reagents in that they are more stable against hydrolysis and retain the positive charge carrying capacity at amine sites at which the modifying reagents are attached.
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Ladd David L.
Snow Robert A.
Davis William J.
Hohenschutz Liza D.
Peabody John
Richter Johann
Sterling Winthrop Inc.
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