Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-12-08
1999-11-09
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514203, 540222, 540225, A61K 31545, C07D50124, C07D50156
Patent
active
059815191
ABSTRACT:
The present invention relates to compounds having the formula ##STR1## wherein X, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.sup.7 are as defined herein as well as readily hydrolyzable esters thereof, pharmaceutically acceptable salts of said compounds and hydrates of the compounds of formula I and of their esters and salts. These compounds have valuable pharmacological activity for the treatment and prophylaxis of infectious diseases, especially those caused by methicillin resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.
REFERENCES:
patent: 5523400 (1996-06-01), Wei et al.
Heinze-Krauss, et al. J. Med. Chem. 39(9) 1996 pp. 1864-1871.
Green, T., "Protective Groups in Organic Synthesis", Chapter 7, pp. 218-287 (1981).
Angehrn Peter
Hebeisen Paul
Heinze-Krauss Ingrid
Page Malcolm
Runtz Valerie
Berch Mark L.
Hoffman-La Roche Inc.
Johnston George W.
Kass Alan P.
Rocha-Tramaloni Patricia S.
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