Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2005-12-27
2005-12-27
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S001210, C424S009321, C424S009510, C554S079000, C554S080000, C554S085000, C568S579000, C568S687000, C514S438000, C514S461000, C514S739000
Reexamination Certificate
active
06979460
ABSTRACT:
A novel amphiphilic lipid compound having a cleavable, vinyl ether linked hydrophilic headgroup is described. Also described are liposomes containing the vinyl ether lipid compound, which may be triggered to release their contents and/or permeablize or fuse with target lipid membranes. The cleavable vinyl ether linkage allows the hydrophilic headgroup to be dissociated from the hydrophobic tailgroup(s) of the lipid compound to facilitate phase transitions in the lipid bilayer.
REFERENCES:
patent: 5277913 (1994-01-01), Thompson et al.
Boomer Jeremy A.
Haynes Robert
Thompson David H.
Coleman Henry D.
Kishore Gollamudi S.
Purdue Research Foundation
Sapone William J.
Sudol R. Nell
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