Vinca derivatives

Details Vinca derivatives Vinca derivatives

2007-10-31

2010-06-29

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07745619

ABSTRACT:
The present invention relates to derivatives of vinca alkaloids. Pharmaceutical compositions containing these compounds as well as processes of preparation and treatment of various conditions are also disclosed.

REFERENCES:
patent: 4307100 (1981-12-01), Langlois et al.
patent: 4347249 (1982-08-01), Potier et al.
patent: 4388305 (1983-06-01), Trouet et al.
patent: 4430269 (1984-02-01), Pearce
patent: 4639456 (1987-01-01), Trouet et al.
patent: 4737586 (1988-04-01), Potier et al.
patent: 4769453 (1988-09-01), Potier et al.
patent: 5047528 (1991-09-01), Kutney et al.
patent: 6127377 (2000-10-01), Duflos et al.
patent: RE37449 (2001-11-01), Kutney et al.
patent: 6365735 (2002-04-01), Rool
patent: 7235564 (2007-06-01), Scott et al.
patent: 7238704 (2007-07-01), Scott et al.
patent: 2004/0186286 (2004-09-01), Fukuyama et al.
patent: 2005/0176748 (2005-08-01), Scott et al.
patent: 2007/0179170 (2007-08-01), Scott et al.
patent: 2007/0179171 (2007-08-01), Scott et al.
patent: 2008/0051425 (2008-02-01), Scott et al.
patent: 2008/0108644 (2008-05-01), Scott et al.
patent: 2008/0119502 (2008-05-01), Wolf et al.
patent: 2008/0125451 (2008-05-01), Wolf et al.
patent: 2 458 600 (2003-03-01), None
patent: 101108859 (2008-01-01), None
patent: 1 426 377 (2004-06-01), None
patent: 2707988 (1995-01-01), None
patent: 2003-064084 (2003-03-01), None
patent: 2005055943 (2005-06-01), None
patent: WO 2005/055943 (2005-06-01), None
patent: 2008/011805 (2008-01-01), None
patent: 2008/033935 (2008-03-01), None
patent: 2008033930 (2008-03-01), None
Keuhne et al. Organic and Biomolecular Chemistry, 2003, 1, 2120-36, available online May 13, 2003.
LaVoie et al. Chemical Reviews, 1996, 96, 3147-76.
Berge et al., “Pharmaceutical Salts,”Journal of Pharmaceutical Sciences66(1):1-19 (1997).
Boyd, M.R., “Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval,” Teicher, B. Ed., Humana Press, Totowa, New Jersey, pp. 23-42 (1997).
Fahy, J., “Modifications in the << upper >> or Velbenamine Part of theVincaAlkaloids Have Major Implications for Tubulin Interacting Activities,”Current Pharmaceutical Design7:1181-1197 (2001).
Lobert et al., “Vinca Alkaloid-Induces Tubulin Spiral Formation Correlates with Cytotoxicity in the Leukemic L1210 Cell Line,”Biochemistry39:12053-12062 (2000).
Ram & Kumari, “Natural Products of Plant Origin as Anticancer Agents,”Drug News Perspect14(8):465-482 (2001).
Skehan et al., “New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening,”Journal of the National Cancer Institute82(13):1107-1112 (1990).
CAS(R) Registry No. 81600-06-8.
CAS(R) Registry No. 123286-01-1; 123286-00-0.
CAS(R) Registry No. 67699-41-6; 67699-40-5.
Anhydrovinblastine,Pioneer, © IMSworld Publications Ltd (2000) (Update Date May 8, 2000).
Vinxaltine; S 12363,Pioneer, © IMSworld Publications Ltd (2000 (Update Date May 22, 1995).
Vinflunine; F 12158; L 0070,Pioneer, © IMSworld Publications Ltd (2000 (Update Date Apr. 19, 1999).
Napavin, Pioneer, © IMSworld Publications Ltd (2000 (Update Date Oct. 25, 1999).
Registry No. 166533-14-8,SciFinder(Feb. 28, 2002).
Registry No. 105801-71-6,SciFinder(Feb. 28, 2002).
Registry No. 105801-70-5,SciFinder(Feb. 28, 2002).
Registry No. 108893-99-8,SciFinder(Feb. 28, 2002).
Registry No. 108893-98-7,SciFinder(Feb. 28, 2002).
Registry No. 218128-76-8,SciFinder(Feb. 28, 2002).
Registry No. 54112-69-5,SciFinder(Feb. 28, 2002).
Registry No. 108893-97-6,SciFinder(Feb. 28, 2002).
Registry No. 108893-96-5,SciFinder(Feb. 28, 2002).
Registry No. 90012-98-9,SciFinder(Feb. 28, 2002).
Registry No. 90012-97-8,SciFinder(Feb. 28, 2002).
Barthe et al., “Optimization of the Seperation of Vinca Alkaloids by Nonaqueous Capillary Electrophoresis,” Journal of Chromatography A 968:241-50 (2002).
International Search Report for International Patent Application No. PCT/US07/78281 (Sep. 3, 2008).
Sheng et al., “Synthesis and Biological Evaluation of C-12' Substituted Vinflunine Derivatives,” Shanghai Hengrui Pharmaceutical Co. Ltd. Shanghai China, Poster Presented at 235th ACS National Meeting, New Orleans, LA (Apr. 6-10, 2008).
Neuss et al., “Vinca Alkaloids XXXIII [1]. Microbiological Conversions of Vincaleukoblastine (VLB, Vinblastine), an Antitumor Alkaloid from Vinca Rosea. Linn.,” Helvetica Chimica Acta 57:1886-90 (1974).
Supplementary European Search Report for European Patent Application No. EP04813012 (May 14, 2009).

Affiliated with

Also associated with

Rating

Vinca derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vinca derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vinca derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4155127