Vinca alkaloid vesicles with enhanced efficacy and tumor targeti

Details Vinca alkaloid vesicles with enhanced efficacy and tumor targeti Vinca alkaloid vesicles with enhanced efficacy and tumor targeti

1997-09-25

1999-03-30

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127, A61K 9133

Patent

active

058885374

ABSTRACT:
A liposome formulation containing a Vinca Alkaloid and an anion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholesterol and disteraroylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.

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Vaage et al., "Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes," Int. J. Cancer 54:959-964, 1993.

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