Vinca-alkaloid vesicles with enhanced efficacy and tumor targeti

Details Vinca-alkaloid vesicles with enhanced efficacy and tumor targeti Vinca-alkaloid vesicles with enhanced efficacy and tumor targeti

1999-03-29

2000-09-19

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127, A61K 9133

Patent

active

061208000

ABSTRACT:
A liposome formulation containing a Vinca Alkaloid and an anion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholesterol and disteraroylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.

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