Vinca alkaloid vesicles with enhanced efficacy and tumor targeti

Details Vinca alkaloid vesicles with enhanced efficacy and tumor targeti Vinca alkaloid vesicles with enhanced efficacy and tumor targeti

1995-02-16

1998-02-03

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

A61K 9127, A61K 9133

Patent

active

057141630

ABSTRACT:
A liposome formulation containing a Vinca Alkaloid and an ion in an aqueous phase of the liposome. The liposomes also comprise distearoylphosphatidyl choline, cholestrol and disteraroylphosphatidylglycerol. A method for enhancing the efficacy and tumor targeting properties of liposomal vinca alkaloid formulations containing unilamellar vesicles.

REFERENCES:
patent: 5019369 (1991-05-01), Present et al.
patent: 5316771 (1994-05-01), Barenholz et al.
Boman, N.L. et al., "Optimization of the retention properties of vincristine in liposomal systems." Biochimica et Biophysica Actd., 1152:pp253-258 (1993).
Boman, N.L. et al., "Liposomal vincristine which exhibits increased drug retention and increased circulation longevity cures mice bearing P388 tumors." Cancer Research 54:pp2830-2833 (Jun. 1, 1994).
Mayer, L.D. et al., "Identification of vesicle properties that enhance the antitumour activity of liposomal vincristine against murine L1210 leukemia." Cancer Chemother Phamacol 33:17-24(199
Vaage, J. et al., "Therapy of mouse mammary carcinomas with vincristine and doxorubicin encapsulated in sterically stabilized liposomes." Int. J. Cancer 54:959-964 (1993).
Forssen, E. et al., "Liposome-entrapped vincristine and mitomycin-C for treatment of solid tumors: i vivo efficacy as a function of co-entrapped counterion." Scientific Proceedings American Association for Cancer Research. 34:365 (1993) Abstract 2176.
Layton, D. et al., "A comparison of the therapeutic effects of free and liposomally encapsulated vincristine in leukemic mice." Europ. J. Cancer 16:945-950 (1980).

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