Vicinal diols

Details Vicinal diols Vicinal diols

1991-04-01

1993-12-28

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548548, 548546, 564152, 564153, C07D40308, C07D40312, C07D40302, C07D207452, C07C10332

Patent

active

052741192

ABSTRACT:
A group of functionalized linking agents are disclosed. The linking agents contain thiol reactive functionalities for the covalent reaction with sulfhydryl groups from the hinge-region of antibody fragments. The linking agents also contain masked aldehyde functionalities for covalent attachment of amine-containing therapeutic agents by Schiff base formation. Carrier systems capable of delivering compounds to targeted sites in vivo based on antigen-antibody interactions are constructed from these linking agents.

REFERENCES:
patent: 5053520 (1991-10-01), Bieniarz et al.

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