Vibrio cholerae having increased sensitivity to antibiotics

Details Vibrio cholerae having increased sensitivity to antibiotics Vibrio cholerae having increased sensitivity to antibiotics

1997-06-26

1999-08-31

Guzo, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352523, 536 231, 536 237, C12Q 168, C12N 120, C07H 2104

Patent

active

059452854

ABSTRACT:
The invention provides bacterial strains with increased sensitivity to antibiotics and methods for making and using the strains.

REFERENCES:
patent: 4882278 (1989-11-01), Mekalanos
patent: 4968619 (1990-11-01), Curtiss, III
patent: 5110588 (1992-05-01), Morona et al.
Pearson et al., "New Attenuated Derivatives of Vibrio cholerae" Res. Microbiol. 141:893-899 (1990).
Sinha et al., "A streptomycin-sensitive revertant of a streptomycin-dependent strain of Vibrio cholerae" Bull. World Health Organ. 53(4):482-484.
Ichinose et al., "The characterization of Vibrio cholerae isolated in Kenya in 1983" Journal of Tropical Medicine and Hygiene 89:269-276 (1986).
Coster et al., "Safety, immunogenicity and efficacy of a live attenuated Vibrio cholerae O139 vaccine protype, Bengal-15", Lancet 345:949-952 (1995).
Mekalanos, "Live bacterial vaccines: environmental aspects", Current Opinion in Biotechnology 5:312-319 (1994).
Mekalanos and Sadoff, "Cholera vaccines: fighting an ancient scourge", Science 265:1387-1389 (1994).
Mekalanos et al., "Live cholera vaccines: perspectives on their construction and safety", Bulletin de I'Institut Pasteur 93:255-262 (1995).
Tacket et al., "Initial clinical studies of CVD112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challenge", J. Infect. Dis. 172:883-886 (1995).
Waldor and Mekalanos, "Emergence of a new cholera pandemic: molecular analysis of virulence determinants in Vibrio cholerae O139 and development of a live vaccine prototype", J. Infect. Dis. 170:278-283 91994).
Waldor and Mekalanos, "Vibrio cholerae O139 specific gene sequences", Lancet 343:1366 (1994).

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