Drug – bio-affecting and body treating compositions – Extract – body fluid – or cellular material of undetermined... – Embryonic structure
Patent
1997-03-26
1998-11-03
Naff, David M.
Drug, bio-affecting and body treating compositions
Extract, body fluid, or cellular material of undetermined...
Embryonic structure
435349, 424 937, A61K 3554, A61K 3512
Patent
active
058305106
ABSTRACT:
A method of producing undifferentiated avian cells expressing an embryonic stem cell phenotype is disclosed. The method comprises collecting avian cells from an avian blastoderm prior to formation of the primitive streak, then depositing the avian cells in contact with a mouse fibroblast feeder cell layer, and then growing the avian cells on the mouse fibroblast feeder cell layer in the presence of a media containing leukemia inhibitory factor in a differentiation-inhibiting amount for a time sufficient to produce a sustained avian cell culture. Cell cultures produced by the aforesaid process and veterinary pharmaceutical formulations containing such cells are also disclosed.
REFERENCES:
M.J. Evans & M.H. Kaufman; Establishment in culture of pluripotential cells from mouse embryos, Nature 292, pp. 154-155 (1981).
G.R. Martin; Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells; Proc. Natl. Acad. Sci. 78, pp. 7634-7638 (1981).
E.J. Sanders & J.E. Dickau; Morphological differentiation of an embryonic epithelium in culture; Cell Tissue Res. 220, pp. 539-548 (1981).
E. Mitrani & H. Eyal-Giladi; Cells from Early Chick Embryos in Culture; Differentiation 21, pp. 56-61 (1982).
A.G. Smith & M.L. Hooper; Buffalo Rat Liver Cells Produce a Diffusible Activity Which Inhibits the Differentiation of Murine Embryonal Carcinoma and Embryonic Stem Cells; Developmental Biology 121, pp. 1-9 (1987).
T. Doetschman et al; Establishment of Hamster Blastocyst-Derived Embryonic Stem (ES) Cell, Developmental Biology 127, pp. 224-227 (1988).
A.H. Handyside et al; Use of BRL-conditioned medium in combination with feeder layers to isolate a diploid embryonal stem cell line, Roux's Arch Dev Biol 198, pp. 48-55 (1989).
J.N. Petitte et al; Abstract Form F114, The Production of Chimeric Chicks by Embryonic Cell Transfer, Journal of Cellular Biochemistry (1989).
J. Nichols et al; Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity, Development 110, pp. 1341-1348 (1990).
S. Pease, et al; Isolation of Embryonic Stem (ES) Cells in Media Supplemented with Recombinant Leukemia Inhibitory Factor (LIF), Developmental Biology 141, pp. 344-352 (1990).
E. Notarianni et al; Maintenance and differentiation in culture of pluripotential embryonic cell lines from pig blastocysts, J. Reprod. Fert. Suppl. 41, pp. 51-56 (1990).
J.A. Piedrahita et al; On the Isolation of Embryonic Stem Cells: Comparative Behavior of Murine, Porcine and Ovine Embryos, Theriogenology 34, pp. 879-901 (1990).
E. Notarianni et al; Derivation of Pluripotent, Embryonic Cell Lines From Porcine and Ovine Blastocysts, World Congress on Genetics Applied to Livestock Productions 14th (1990).
A.G. Smith; Culture and Differentiation of Embryonic Stem Cells, J. Tiss. Cult. Meth. 13, pp. 89-94 (1991).
Petitte James N.
Yang Zengming
Kerr Janet M.
Naff David M.
North Carolina State University
LandOfFree
Veterinary pharmaceutical formulation containing avian embryonic does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Veterinary pharmaceutical formulation containing avian embryonic, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Veterinary pharmaceutical formulation containing avian embryonic will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-686909