Vesicle transport protein

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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530350, C07K 1600, C07K 1400

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active

061629014

ABSTRACT:
The invention provides a human vesicle transport protein (NVTP-1) and polynucleotides which identify and encode NVTP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NVTP-1.

REFERENCES:
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Berendsen, A glimpse of the holy grail, Science, vol. 282, pp. 642-643, Oct. 1998.
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Rothman, J.E., et al., "Protein Sorting by Transport Vesicles", Science, 272:227-234 (1996). (GI 642025) (GI 642026).
Tellam, J. T., et al., "Molecular Identification of Two Novel Munc-18 Isoforms Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 270:5857-5863 (1995).
Hata, Y., et al., "A Novel Ubiquitous Form of Munc-18 Interacts with Multiple Syntaxins", Journal of Biological Chemistry, 270:13022-13028 (1995).
Katagiri, H., et al., "A Novel Isoform of Syntaxin-binding Protein Homologous to Yeast Secl Expressed Ubiquitously in Mammalian Cells", Journal of Biological Chemistry, 270:4963-4966 (1995).
Fujita, Y., et al., "Phosphorylation of Munc-18
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Veerasamy, R., et al., "Identification of a Novel Syntaxin-and Synaptobrevin/VAMP-binding Protein, SNAP-23, Expressed in Non-neuronal Tissues", Journal of Biological Chemistry, 271:13300-13303 (1996).

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