Vesicle stabilization

Details Vesicle stabilization Vesicle stabilization

1988-10-11

1991-04-16

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

264 41, 264 43, 424 11, 424450, 424484, 424485, 424488, 4284022, 436829, 514937, 514944, 514963, 514965, A61F 1300, A61K 9127, A61K 4736, A61K 4742

Patent

active

050081098

ABSTRACT:
The present invention relates to a process of stabilizing micellular particles such as vesicles and increasing the shelf life by suspending the particles in a polymeric gel matrix. The invention also relates to such particles suspended in the gel matrix with a protective gel surface thereabout which is capable of becoming fluid and converting the protective surface of an aqueous suspension.

REFERENCES:
patent: 3527712 (1970-09-01), Renn et al.
patent: 3619842 (1971-11-01), Maierson
patent: 4185618 (1980-01-01), Corey
patent: 4217344 (1980-08-01), Vanlerberghe et al.
patent: 4235871 (1980-11-01), Papahadjopoulos et al.
patent: 4310506 (1982-01-01), Baldeschwieler et al.
patent: 4439488 (1984-03-01), Trimnell et al.
patent: 4493894 (1985-01-01), Miyashiro et al.
"Carbopol Scales Up", Chemistry and Engineering News, 36, 64 & 65, Sep. 29, 1958.
The United States Pharmacopoeia-National Formulary Monograph, 1985, p. 1542.
Mauk et al., "Preparation of Lipid Vesicles Containing High Levels of Entrapped Radioactive Cations", Analytical Biochemistry, vol. 94, pp. 302-307, (1979).
Mauk et al., "Stability of Lipid Vesicles in Tissues of the Mouse", Proc. Natl. Acad. Sci. U.S.A., vol. 76, No. 2, pp. 765-769, (1979).
Frokjaer et al., "Stability and Storage of Liposomes", in Optimization of Drug Delivery, Alfred Benzon Symposium, 17, Bundgaard et al., Eds., Munksgaard, Copenhagen, pp. 384-397, (1982).
Weinstein et al., "Liposomes and Local Hyperthermia", Science, vol. 204, pp. 188-191, (1979).
Sheetz et al., "Effect of Sonication on the Structure of Lecithin Bilayers", Biochemistry, vol. 11, No. 24, pp. 4573-4581, (1972).
Lawaczeck et al., "The Formation and Annealing of Structural Defects in Lipid Bilayer Vesicles", Biochimica et Biophysica Acta, vol. 443, pp. 313-330, (1976).
Schullery et al., "Fusion of Dipalmitoyl Phosphatidylcholine Vesicles", Biochemistry, vol. 19, pp. 3919-3923, (1980).
Abra et al., "Liposome Disposition in Vivo", Biochimica et Biophysica Acta, vol. 666, pp. 493-503, (1981).
Kao et al., "Interactions of Liposomes with the Reticuloendothelial System", Biochimica et Biophysica Acta, vol. 677, pp. 453-461, (1981).
Ryman et al., "Potential Applications of Liposomes to Therapy", Annals N.Y. Acad. Sci., vol. 308, pp. 281-307, (1978).
Fendler, "Surfactant Vesicles as Membrane Mimetic Agents", Acc. Chem. Res., vol. 13, pp. 7-13, (1980).
Chemical Abstracts No. 188 156K (vol. 97, No. 22, Nov. 29, 1982).
Chemical Abstracts No. 187329V, (vol. 94, No. 23, Jun. 8, 1981).

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