Vesicle including a metal marker for use in an assay

Details Vesicle including a metal marker for use in an assay Vesicle including a metal marker for use in an assay

1985-04-05

1987-11-17

Rosen, Sam

Chemistry: analytical and immunological testing

Biospecific ligand binding assay

436528, 436544, 436546, 436800, 436808, 436829, G01N 33533, G01N 33546

Patent

active

047074531

ABSTRACT:
Vesicles are formed, in part, from an amphiphilic chelating agent whereby a detectable metal marker can be complexed to the vesicle. A portion of the vesicle may also be formed from an amphiphilic compound derivatized with a ligand, whereby the vesicle may be used as a tracer in an assay. If the detectable metal marker is a fluorescent rare earth metal, the assay may be a time delay fluorescent assay. The vesicles may be dried, and reformed by addition of water for use in an assay.

REFERENCES:
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patent: 4224179 (1980-09-01), Schneider
patent: 4235871 (1980-11-01), Padamadjopoulos et al.
patent: 4283382 (1981-08-01), Frank et al.
patent: 4374120 (1983-02-01), Soini et al.
patent: 4432907 (1984-02-01), Wieder et al.
patent: 4483929 (1984-11-01), Szoka
A. White et al., Principles of Biochemistry, 3rd Editon, McGraw-Hill Book Co., New York, pp. 187-191, 1964.

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