Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1991-11-18
1993-02-16
Lovering, Richard D.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
264 41, 264 43, 424 11, 4284022, 514823, 514885, 514963, A61K 9127, A61K 9133
Patent
active
051869411
ABSTRACT:
Disclosed herein are vesicle compositions for controlled sustained release of an encapsulated therapeutic agent after parenteral administration. By adjusting the osmolarity between the suspending solution and the solution within the vesicles by adjusting the concentration of the suspending solution, the rate of release of the therapeutic agent after parenteral administration can be varied. The compositions can be effectively administered by intramuscular, subcutaneous injection or other means.
REFERENCES:
patent: 4089801 (1978-05-01), Schneider
patent: 4186183 (1980-01-01), Steck et al.
patent: 4224179 (1980-09-01), Schneider et al.
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4342826 (1982-08-01), Cole
patent: 4411894 (1981-01-01), Shrank et al.
patent: 5094854 (1992-03-01), Ogawa et al.
R. Bittman, et al., "Osmotic Behavior of Liposomes of Phosphatidylcholine and Phosphatidylsulfocholine as a Function of Lipid Concentration", 28(4) Chem. Phys. Lipids pp. 323-335 (1981).
Abra, R. M. and Hunt, C. A., 666 Biochimica et Biophysica Acta, pp. 493-530 (1981).
Allen, J. M., and Cleland, L. G., 597 Biochimica et Biophysica Acta, pp. 418-526 (1980).
Allen and Everest, 226 The Journal of Pharmacology and Experimental Therapeutics, No. 2, pp. 539-544.
Osol et al., The United States Dispensatory, 27th Edition, J. B. Lippincott Co., Philadelphia, Toronto (1973), pp. 950-951.
Arakawa, E., 23 Chemical and Pharmaceutical Bulletin of Japan, pp. 2218-2222 (1975).
Bangham, 1 Chemistry and Physics of Lipids, pp. 245-246 (1967).
Burdgaard, H., editor, Alfred Benzoin Symposium #17, Optimization of Drug Delivery, p. 400 (Copenhagen 1982).
Juliano, R. L., 56 Canadian Journal of Physiology and Pharmacology, No. 5, pp. 683-690 (1978).
Kimelberg, 448 Biochimica et Biophysica Acta, pp. 531-550 (1976).
Callahan Richard A.
Tin George W.
Lovering Richard D.
Vestar, Inc.
LandOfFree
Vesicle formulation for the controlled release of therapeutic ag does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vesicle formulation for the controlled release of therapeutic ag, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vesicle formulation for the controlled release of therapeutic ag will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2146925