Very low temperature casting of controlled release microspheres

Details Very low temperature casting of controlled release microspheres Very low temperature casting of controlled release microspheres

1989-05-01

1991-05-28

Lovering, Richard D.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

264 9, 264 13, 264 14, 264 28, 424489, 424490, 424499, 4272133, 42721336, 427212, 42840224, 523223, A61K 958, B29B 900, C08K 716, B01J 1302

Patent

active

050194003

ABSTRACT:
A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolved in the solvent or dispersed in the solvent in the form of microparticles. The polymer/active agent mixture is atomized into a vessel containing a liquid non-solvent, alone or frozen and overlayed with a liquified gas, at a temperature below the freezing point of the polymer/active agent solution. The cold liquified gas or liquid immediately freezes the polymer droplets. As the droplets and non-solvent for the polymer is warmed, the solvent in the droplets thaws and is extracted into the non-solvent, resulting in hardened microspheres.

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