Very large scale immobilized polymer synthesis using mechanicall

Details Very large scale immobilized polymer synthesis using mechanicall Very large scale immobilized polymer synthesis using mechanicall

1991-11-22

1995-01-24

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

436527, 436531, 436532, 436501, 436809, 436807, 435 71, 435968, 435969, 435970, 435973, 530334, 530335, 530337, 422134, 422149, G01N 33543

Patent

active

053842618

ABSTRACT:
A method and device for forming large arrays of polymers on a substrate (401). According to a preferred aspect of the invention, the substrate is contacted by a channel block (407) having channels (409) therein. Selected reagents are flowed through the channels, the substrate is rotated by a rotating stage (403), and the process is repeated to form arrays of polymers on the substrate. The method may be combined with light-directed methodolgies.

REFERENCES:
patent: 3848998 (1974-11-01), Yonekura et al.
patent: 4166457 (1979-09-01), Jacobsen et al.
patent: 4392362 (1983-07-01), Little
patent: 4598049 (1986-07-01), Zelinka et al.
patent: 4668476 (1987-05-01), Bridgham et al.
patent: 4704256 (1987-11-01), Hood et al.
patent: 4728502 (1988-03-01), Hamill
patent: 4746490 (1988-05-01), Saneii
patent: 4861420 (1989-08-01), Knutti et al.
patent: 4861866 (1989-08-01), Durrum et al.
patent: 4943032 (1990-07-01), Zdeblick
patent: 4966646 (1990-10-01), Zdeblick
patent: 4997521 (1991-03-01), Howe et al.
patent: 5026773 (1991-06-01), Steel
patent: 5037882 (1991-08-01), Steel
patent: 5053454 (1991-10-01), Judd
patent: 5100626 (1992-03-01), Levin
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5175209 (1992-12-01), Beattie et al.
Sze, "Lithography" Chapter 7, VLSI Technology, McGraw-Hill Book Company, 1983, pp. 267-301.
Abbott et al., "Manipulation of the Wettability on Surfaces on the 0.1-to 1-Micrometer Scale Through Micromachining and Molecular Self-Assembly, " Science (1992) 257:1380-1382.
Bhatia et al., "New Approach to Producing Patterned Biomolecular Assemblies," J. Am. Chem. Soc. (1992) 114:4432-4433.
Haridasan et al., "Peptide Synthesis Using Photolytically Cleavable 2-Nitrobenzyloxycarbonyl Protecting Group," Proc. Indian Natl. Sci. Acad. (1987) 53:717-728.
Frank et al., "Simultaneous Multiple Peptide Synthesis Under Continuous Flow Conditions on Cellulose Paper Discs as Segmental Solid Supports", Tetrahedron 44:6031-6040 (1988).
Knutti, "Silicon Microsystems as an Industry," presented at Microsystems 1990; Sep. 10-13, Berlin Germany.
Knutti, "Emerging Silicon Microstructures," Undated.
Knutti, "Advanced Silicon Microstructures," presented at ASICT Conference; Apr. 11, 1989; Toyohashi, Japan.
Fodor et al., Science (1991) 251:767-777.
Frank et al., Nucleic Acids Research (1983) 11:4365-4377.

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