Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1991-12-06
1995-06-13
Kepplinger, Esther M.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436518, 436527, 436528, 436809, 436 253, 436 2531, 436 2532, C12Q 168, C07H 100
Patent
active
054241863
ABSTRACT:
A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.
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Fodor Stephen P. A.
Pirrung Michael C.
Read J. Leighton
Stryer Lubert
Affymax Technologies N.V.
Green Lora M.
Kaster Kevin R.
Kepplinger Esther M.
Norviel Vern
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