Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Reexamination Certificate
2005-07-12
2005-07-12
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
C536S023100, C536S023200, C536S024300, C536S024310, C435S006120, C435S320100, C435S325000, C435S252300, C435S254200, C435S353000, C435S354000, C435S363000, C435S366000
Reexamination Certificate
active
06916642
ABSTRACT:
Nucleic acid molecules encoding vertebrate telomerase are provided. Gene products, expression vectors and host cells suitable for expressing telomerase are also provided. Methods for identifying inhibitors of telomerase activity and inhibitor compositions are disclosed.
REFERENCES:
patent: 5489508 (1996-02-01), West et al.
patent: 5639613 (1997-06-01), Shay et al.
patent: 5645986 (1997-07-01), West et al.
patent: 5770422 (1998-06-01), Collins
patent: 5919656 (1999-07-01), Harrington et al.
patent: 6093809 (2000-07-01), Cech et al.
patent: 6166178 (2000-12-01), Cech et al.
patent: 6309867 (2001-10-01), Cech et al.
patent: WO 95/13382 (1995-05-01), None
patent: WO 96/01835 (1996-01-01), None
patent: WO 96/19580 (1996-06-01), None
patent: WO 98/11207 (1998-03-01), None
patent: WO 98/14592 (1998-04-01), None
patent: WO 98/14593 (1998-04-01), None
patent: WO 98/21343 (1998-05-01), None
patent: WO 98/37181 (1998-08-01), None
Wick M. et al. Genomic organization and promoter characterization of the gene encoding the human telomerase reverse transcriptase (hTERT), Gene, 1999, 232, 97-106.
Leem S-H. et al. The human telomerase gene: complete genomic sequence and analysis of tandem repeat polymorphism in intronic regions, Oncogene, 2002, 21, 769-777.
Adams et al., “EST12462 Uterus Tumor IHomo sapienscDNA 5' End,”EMBL Database Entry HSZZ05016:Accession No. AA299878, 1997.
Belair et al., “Telomerase Activity: A Biomarker of Cell Proliferation, Not Malignant Transformation,”Proc. Natl. Acad. Sci. USA 94:13677-13682, 1997.
Holt et al., “Lack of Cell Cycle Regulation of Telomerase Activity in Human Cells,”Proc. Natl. Acad. Sci. USA 94:10687-10692, 1997.
Kilian et al., “Isolation of a Candidate Human Telomerase Catalytic Subunit Gene, Which Reveals Complex Splicing Patterns in Different Cell Types,”Human Molecular Genetics 6(12):2011-2019, 1997.
Kim et al., “Specific Association of Human Telomerase Activity with Immortal Cells and Cancer,”Science 266:2011-2015, 1994.
Lingner et al., “Reverse Transcriptase Motifs in the Catalytic Subunit of Telomerase,”Science 276:561-567, 1997.
Meyerson et al., “hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and During Immoralization,”Cell 90:785-795, 1997.
Nakamura et al., “Telomerase Catalytic Subunit Homologs from Fission Yeast and Human,”Science 277:955-958, 1997.
Nakayama et al., “TLP1, A Gene Encoding a Protein Component of Mammalian Telomerase Is a Novel Member of WD Repeats Family,”Cell 88:875-884, 1997.
Ngo et al., “Computational Complexity, Protein Structure Prediction, and the ILevinthal Paradox,”The Protein Folding Problem and Tertiary Structure Prediction, Merz et al. (eds.), Birkhauser et al., Boston, MA, 1994, pp. 491-495.
Raymond et al., “Agents that Target Telomerase and Telomeres,”Current Opinion in Biotechnology 7:583-591, 1996.
Rudinger, “Characteristics of the Amino Acids as Components of a Peptide Hormone Sequence,” inPeptide Hormones, J. A. Parsons (ed.), University Park Press, Baltimore, MD, 1976, pp. 1-7.
Thornton et al., “Protein Engineering: Editorial Overview,”Current Opinion in Biotechnology 6(4):367-369, 1995.
Wallace, “Understanding Cytochrome c Function: Engineering Protein Structure by Semisynthesis,”The FASEB Journal 7:505-515, 1993.
Bowtell David
Kilian Andrzej
Nottenburg Carol
Prouty Rebecca E.
The Monticello Group, LTD
Walicka Malgorzata A.
LandOfFree
Vertebrate telomerase genes and proteins and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vertebrate telomerase genes and proteins and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vertebrate telomerase genes and proteins and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3402848