Vertebrate poxvoris expression vector under the control of entom

Details Vertebrate poxvoris expression vector under the control of entom Vertebrate poxvoris expression vector under the control of entom

1991-01-08

1994-08-16

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Virus or bacteriophage, except for viral vector or...

4353201, 4241991, 4242321, 536 241, C12N 701, C12N 1586, C12N 1511, A61K 39275

Patent

active

053386795

ABSTRACT:
Disclosed is a recombinant vertebrate F such as vaccinia virus which comprises in its genome (i) spheroidin promoter of entomopoxvirus such as Choristoneura biennis and (ii) at least one structural gene coding for at least one protein foreign to entomopoxvirus and to the vertebrate poxvirus and is capable of expressing the foreign protein gene in a vertebrate tissue culture cell or in a vertebrate animal susceptible to the vaccinia virus. The recombinant virus is capable of expressing the foreign gene at a significantly higher rate due to the presence of the entomopoxvirus spheroidin promoter than the same virus without the entomopoxvirus promoter. The protein may be antigenic or otherwise pharmaceutically useful. Also disclosed vaccine and a process for producing the protein using the recombinant virus.

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