Vertebrate embryonic patterning-inducing proteins,...

Details Vertebrate embryonic patterning-inducing proteins,... Vertebrate embryonic patterning-inducing proteins,...

2006-12-05

2006-12-05

Andres, Janet L. (Department: 1649)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S069300, C435S252300, C435S325000, C436S501000, C530S300000, C530S350000, C514S002600

Reexamination Certificate

active

07144997

ABSTRACT:
It is shown here that hedgehog proteins possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog is also trophic for dopaminergic neurons. Interestingly, hedgehog not only promotes dopaminergic neuron survival, but also promotes the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.

REFERENCES:
patent: 4456687 (1984-06-01), Green
patent: 5223408 (1993-06-01), Goeddel et al.
patent: 5519035 (1996-05-01), Maiese et al.
patent: 5585087 (1996-12-01), Lustig et al.
patent: 5643915 (1997-07-01), Andrulis, Jr. et al.
patent: 5747507 (1998-05-01), Ikegaki et al.
patent: 5759811 (1998-06-01), Epstein et al.
patent: 5789543 (1998-08-01), Ingham et al.
patent: 5837538 (1998-11-01), Scott et al.
patent: 5844079 (1998-12-01), Ingham et al.
patent: 3942114 (1990-06-01), None
patent: 0187 371 (1986-07-01), None
patent: 0249 873 (1987-06-01), None
patent: 0457295 (1991-11-01), None
patent: 0464206 (1992-01-01), None
patent: 0874 048 (1998-10-01), None
patent: 0874048 (1998-10-01), None
patent: 0874048 (1998-10-01), None
patent: 0879888 (1998-11-01), None
patent: 63 08 81 12 (1988-04-01), None
patent: 02 27 36 10 (1990-11-01), None
patent: 04 30 55 28 (1992-10-01), None
patent: WO 90/02809 (1990-03-01), None
patent: WO 92/15679 (1992-09-01), None
patent: WO 93/08809 (1993-05-01), None
patent: WO 94/02488 (1994-02-01), None
patent: WO 94/28016 (1994-12-01), None
patent: WO 95/18856 (1995-07-01), None
patent: WO 95/23223 (1995-08-01), None
patent: WO 96/09806 (1996-04-01), None
patent: WO 96/11260 (1996-04-01), None
patent: WO 96/16668 (1996-06-01), None
patent: WO 96/17924 (1996-06-01), None
patent: WO 97/11095 (1997-03-01), None
patent: WO 97/45541 (1997-12-01), None
patent: WO 98/12326 (1998-03-01), None
patent: WO 98/14475 (1998-04-01), None
patent: WO 98/21227 (1998-05-01), None
patent: WO 98/30234 (1998-07-01), None
patent: WO 98/30576 (1998-07-01), None
patent: WO 98/35020 (1998-08-01), None
patent: WO 99/00117 (1999-01-01), None
patent: WO 99/00403 (1999-01-01), None
patent: WO 99/01468 (1999-01-01), None
patent: WO 99/04775 (1999-02-01), None
patent: WO 99/10004 (1999-03-01), None
patent: WO 99/39725 (1999-08-01), None
Hillier et al., Genome Res., vol. 6, pp. 807-828.
Marigo et al. Genomics, vol. 28 pp. 44-51.
GenEmbl., Acc. L38517.
Wang et al. Nature Med., vol. 1, pp. 1184-1188.
Hammerschmidt et al., Genes & Development, vol. p. 647-658, Feb. 1996.
Ayala et al., Modern Genetics, p. 678, 1998.
Miao, N. et al., “Sonichedgehogpromotes the survival of specific CNS neuron populations and protects these cells from toxic insultin vitro,” Journal of Neuroscience, 17:15, 1997, 5891-5899.
FDC Reports, Accession No. 580300025, The Pink Sheet, 58:30, Jul. 22, 1996.
Hynes, M., et al., “Induction of midbrain dopaminergic neurons by Sonichedgehog,” Neuron, 15:1, Jul. 1995, 35-44.
Wang, M. Z. et al., “Induction of dopaminergic neurons phenotype in the midbrain by Sonichedgehogprotein.” Nature Medicine, 1:11, Nov. 1995, 1184-1188.
Hulley, P. et al., “Cyclic AMP promotes the survival of dopaminergic neurons in vitro and protects them from toxic effects of MPP+.” Journal of Neural Transmission, Supplementum. 46, 1995, 217-228.
Michel, P.P. et al., “Chronic activation of the cyclic AMP signaling pathway promotes development and long-term survival of mesencephalic dopaminergic neurons.” Journal of Neurochemistry, 67:4, 1996, 1633-1642.
Huang, X. et al., “Cyclic AMP improves the in vitro survival of mesencephalic dopaminergic neurons by decreasing apoptotic cell death.” Society for Neuroscience Abstracts, 22:1-3, 1996, 565.
Epstein, D.J. et al., “Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonichedgehogsignaling pathway.” Development, 122:9, Sep. 1996, 2885-2894.
Hammerschmidt, M. et al., “Protein Kinase A is a common negative regulator ofHedgehogsignaling in the vertebrate embryo.” Genes and Development, 10:6, Mar. 15, 1996, 647-658.
Marigo, V. et al., “Regulation of patched by sonichedgehogin the developing neural tube.” Proceedings of the National Academy of Sciences of the U.S.A., 93:18, Sep. 3, 1996, 9346-9351.
Miao, N. et al., “A neurotrophic activity of sonichedgehogpromotes the survival of dopaminergic neurons.” Cell Transplantation, 5:5, 1996, 17.
Hartikka, J. et al., “Cyclic AMP, but no basic FGi, increases the in vitro survival of mesencephalic dopaminergic neurons and protects them from MPR+ induced degeneration.” Journal of Neuroscience, Research, 32:2, Jun. 1992, 190-201.
Drummond, I.A. Human deserthedgehog. NCBI Access No. AAB03398, submitted (Jun. 2, 1996).
Anderson, R. et al., “Maintenance of ZPA signaling in cultured mouse limb bud cells”,Devel.117:1421-1433 (1993).
Angier, N., “Biologists find key genes that shape patterning of embryos”,New York Times, Jan. 11, 1994, C-1.
Basier, K. and G. Struhl, “Compartment boundaries and the control ofDrosophilalimb pattern by Hedgehog protein”,Nature368:208-214 (1994).
Basier, K. et al., “Control of cell pattern in the neural tube: Reulation of cell differentiation by dorsalin-1, a novel TGFβ family member”,Cell73:687-702 (1993).
Bass, S. et al., “Hormone phage: An enrichment method for variant proteins with altered binding properties”,PROTEINS: Stucture, Function, and Genetics8:309-314 (1990).
Bejsovec, A. and E. Wieschaus, “Segment polarity gene interactions modulate epidermal patterning inDrosphilaembryos”,Development119:501-517 (1993).
Bienz, M., “Homeotic genes and positional signalling in theDrosophila viscera”,TIG10:22-26 (Jan. 1994).
Bitgood, M. and A. McMahon, “Hedgehogand Bmp genes are coexpressed at many diverse sites of cell-cell cnteraction in the mouse embryo”,Dev. Biol.172(1):126-138 (1995).
Blair, S. S., “Hedghogdigs up an old friend”,Nature, 373:656-657 (Feb. 23, 1995).
Brand-Saberi, B. et al., “The ventralizing effect of the notochord on somite differentiation in chick embryos”,Anat. Embryol.188:239-245 (1993).
Brockes, J., “We may not have a morphogen”,Nature350:15 (1991).
Bumcrot, D. A. et al., “Proteolytic processing yields two secreted forms of sonichedgehog”,Mol. Cell. Biol.15(4):2294-2303 (Apr. 1995).
Bumcrot, D. A. and A. McMahon, “Sonichedgehog: Making the gradient”,Chem. Biol.3(1):13-16 (Jan. 1996).
Bumcrot, D. A. and A. McMahon, “Somite differentiation. Sonic signals somites”,Curr. Biol.5(6):612-614 (Jun. 1995).
Charite, J. et al., “Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forlimb and homeotic transformation of axial structures”,Cell78:589-601 (1994).
Coffman, et al., “Xotch, the Xenopus homolog ofDrosophilanotch”,Science249:1438-1441 (1990).
Concordet, J. and P. Ingham, “Developmental biology. Patterning goes sonic”,Nature375(6529):279-280 (May 1995).
Curry, et al., “Sequence analysis reveals homology between two proteins of the flagellar radial spoke”,Mol. Cell. Biol.12:3967-3977 (1992).
Davidson, E. H., “How embryos work: a comparative view of diverse modes of cell fat specification”,Develop.108:365-389 (1990).
Davis, A. P. and M. R. Capecchi, “Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-1”,Devel.120:2187-2198 (1994).
Dickinson, W., “Molecules and morphology: Where's the homology”,TIG11(4):119-120 (1995).
Dingemanse, M. A. et al., “The expression of liver-specific genes within rat embryonic hepatocytes is a discontinous process”,Differentiation56:153-162 (1994).
Dollé, P. et al., “Coordinate expression of the murine Hox-5 complex homeobox-containing genes during limb pattern formation”,Nature342:767-772 (1989)

Affiliated with

Also associated with

Rating

Vertebrate embryonic patterning-inducing proteins,... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Vertebrate embryonic patterning-inducing proteins,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vertebrate embryonic patterning-inducing proteins,... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3704381