Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-06-28
2005-06-28
Helms, Larry R. (Department: 1642)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S387100, C530S387900
Reexamination Certificate
active
06911532
ABSTRACT:
The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.
REFERENCES:
patent: 5082774 (1992-01-01), Heinrich
patent: 252685 (1988-01-01), None
patent: WO 95/00642 (1995-01-01), None
Kobayashi et al (Dec. 1990, Proc Natl Acad Sci U S A., vol. 87, pp. 9620-9624).
Yonehara et al. (Jul. 26, 1991, Cell, vol. 66, pp. 233-243.
Merriam-Webster Dictionary downloaded on Dec. 10, 2003 from url>>> M-W.com.
Allsop et al., “The proto-oncogene bcl-2 can selectivley rescue neurotic factor-dependant neurons from apoptosis,”Cell,73:295, 1993.
Bakhshi et al., “Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around JHon chromosome 14 and near a transcriptional unit on 18,”Cell,41:899, 1985.
Boise et al., “bcl-x, a bcl-2 related gene that functions as a dominant regulator of apoptotic cell death,”Cell,74:597-608, 1993.
Borzill et al., “Bcl-2 confers growth and survival advantage to interleukin 7-dependant early pre-B cells which become factor independent by a multistep process in culture,”Oncogene,7:869, 1992.
Bracci-Laudiero et al., “NGF retards apoptosis in chick embryo bursal cell in vitro,”Differentiation,53:61-66, 1993.
Brown,Washington Post,A1 and A22, Dec. 8, 1995.
Cazals-Hatem, “Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein,”Biochimica et Biophysica Acta,1132:109-113, 1992.
Chen-Levy and Cleary, “Membrane topology of the Bcl-2 proto-onogenic protein demonstrated in vitro,”J. Biol. Chem.,265:4929, 1990.
Chen-Levy et al., The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation,:Mol. Cell. Bio.,9:701, 1989.
Clarke et al., “A recombinant bcl-xsadenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells,”Proc. Natl.Acad. Sci. USA,92:11024-11028, 1995.
Cleary et al., “Cloning and structural analysis od cDNAs for bcl-2 and a hybrid bcl-2/immunoglobin transcript resulting from the t(14;18) translation,”Cell,47:19, 1986.
Cuende et al., “Programmed cell death by bcl-2-dependant and independent mechanisms in B lymphoma cells,”The EMBO Journal,12(4):1555-1560, 1993.
Day, “How to write and publish a scientific paper,” ISI Press, Philadelphia, PA, pp. 15-19, 1983.
Dole et al., “Bcl-xLis expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis,”Cancer Research,55:2576-2582, 1995.
Eguchi et al., “Isolation and characterization of the chicken bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo,”Nucleic Acids Research,20:4187-4192, 1992.
Ellis et al., “Mechanisms and functions of cell death,”Annu. Rev. Cell. Biol.,7:663-698, 1991.
Fang et al., “Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes,”J. Immunology,153:4388-4398, 1994.
Federoff et al., “Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia,”Proc. Natl. Sci. USA,89:1636-1640, 1992.
Frankowski et al “Function and expression of the Bcl-x gene in the developing and adult nervous system,”NeuroReport,6:1917-1921, 1995.
Garcia et al., Prevention of programmed cell death of sympathetic neurons by the bcl-2 prot-oncogene,Science,258:302, 1992.
Gonzalez-Garcia et al., “bcl-xLis the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondra,”Development,120:3033-3042, 1994.
Graninger et al., “Expression of bcl-2 and bcl-2-lg fusion transcripts in normal and neoplastic cells,”J. Clin. Invest.,80:1512, 1987.
Gregory et al., “Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis,”Nature,349:612-614, 1991.
Hockenberry et al., “Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death,”Nature,348:334, 1990.
Jaattela et al., “Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2in breast carcinoma cells,”Oncogene,10:2297-2305, 1995.
Jasty et al., “bcl-xLa gene which regulates programmed cell death, is expressed in neuroblastoma tumor cell lines,”Clinical Research,42:416A, 1994.
Jensen et al., “Steady-state polypeptide modulations associated with nerve growth factor (NGF)-induced terminal differentiation and NGF deprivation-induced apoptosis in human neuroblastoma cells,”J. Biol. Chemistry,267(27):19325-19333, 1992.
Kawabe and Ochi “Programmed cell death and extrathymic reduction of Vβ8+CD4+cells in mice tolerant tostaphylococcus aureusenterotoxin B,”Nature,349:245, 1991.
Kawaja et al., “Somatic gene transfer of nerve growth factor promotes the survival of axotomized septal neurons and the regeneration of their axons in adult rats,”J. Neuroscience,12:2849-2864, 1992.
Kerr et al., “Apoptosis: A basic biological phenomenon with wide-ranging implication in tissue kinetics,”Br. J. Cancer,26:239-257, 1972.
Korsmeyer, “Chromosomal translocation in lymphoid malignancies reveal novel proto-oncogenes,”Annu. Rev. Immunol.,10:785-807, 1992.
Kozopas et al., “MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to bcl-2,”Proc. Natl. Acad. Sci. USA,90:3516-3520, 1993.
Krajewski et al., “Immunohistochemical analysis of in vivo patterns of Bcl-X expression1,”Cancer Research,54:5501-5507, 1994.
Kramer et al., “Self-specific T lymphocyte lines as vehicles for gene therapy: Myelin specific T cells carrying exogenous nerve growth factor gene,”J. Cell Biochem.,17 Part E: 228, 1993.
Marshall, “Gene therapy's growing pains,”Science,269:1050-1055, 1995.
McCarthy et al., “Apoptosis in the development of the immune system: Growth factors, clonal selection and bcl-2,”Cancer Metastasis Reviews,11:157-178, 1992.
Mesner et al., “Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons,”J. Cell Biol.,119:1669-1680, 1992.
Nunez et al., “Bcl-x is expressed in embryonic and adult neuronal tissues and its expression prevents neuronal cell death,”J. Cellular Biochem.,19B:317, Abstract # B8-438, 1995.
Nunez et al., “Deregulated bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines,”J. Immuno.,144:3602, 1990.
Oltval et al., “Bcl-2 heterodimerizes in vitro with a conserved homolog, bax, that accelerates programmed cell death,”Cell,74:609-619, 1993.
Oppenheim et al., “Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death,”Nature,360:755-757, 1992.
Oppenheim, “Cell death during development of the nervous system,”Annu. Rev. Neurosci.,14:453-501, 1991.
Orkin et al., “Report and recommendations of the panel to asses the NIH investment in research on gene therapy,” (report), Dec. 7, 1995.
Raff, “Social controls on cell survival and cell death,”Nature,356:397-400, 1992.
Reed et al., “Regulation of bcl-2 proto-oncogene expressio
Boise Lawrence H.
Nuñez Gabriel
Thompson Craig B.
Fulbright & Jaworski LLP
Helms Larry R.
The Reagents of the University of Michigan
Yu Misook
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