Vertebrate apoptosis gene: compositions and methods

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4352533, 4353201, 435325, 435358, 435365, 435356, 435367, 435366, 435354, 435369, 435364, 435350, 536 235, 536 2431, 536 2433, C12N 510, C12N 512

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056460082

ABSTRACT:
The invention relates generally to compositions of and methods for obtaining and using a polypeptide other than BCL-2 that affects programmed vertebrate cell death. The invention relates as well to polynucleotides encoding those polypeptides, recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant polypeptides. The invention further provides methods for using the isolated, recombinant polypeptides in assays designed to select and improve substances capable of altering programmed cell death for use in diagnostic, drug design and therapeutic applications.

REFERENCES:
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