Velocity modulated capillary electrophoresis analysis system

Details Velocity modulated capillary electrophoresis analysis system Velocity modulated capillary electrophoresis analysis system

1988-11-22

1990-03-20

Niebling, John F.

Chemistry: electrical and wave energy

Apparatus

Coating, forming or etching by sputtering

2041801, 2041833, B01D 5702, G01N 2728

Patent

active

049099191

ABSTRACT:
A capillary zone electrophoresis system with analyte velocity modulation is described. Velocity modulation of the analyte is provided through applying an AC component to the DC driving potential applied to the separation capillary. Typically modulation on the order of 20 to 30% is applied by a separate AC power supply or an integral DC/AC source. Numerous types of detector systems can be employed including refractive index detectors, conductance, fluorescence, etc. The output of the detector is demodulated using a synchronous demodulation. The velocity modulation generates a signal which is a derivative of the conventional concentration/time signal. The system vastly improves detector sensitivity in situations where limitations are imposed by the large and variable background signals which arise from the aqueous buffer itself. Numerous embodiments of means for applying the modulated driving potential are described along with several detectors which can be implemented in systems according to this invention.

REFERENCES:
Chen, C. Y. et al, "Capillary Zone Electrophoresis with Analyte Velocity Modulation, Application to Refractive Index Detection" Analytical Chemistry, 61(14) (1989), pp. 1590-1593.

Affiliated with

Also associated with

Rating

Velocity modulated capillary electrophoresis analysis system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Velocity modulated capillary electrophoresis analysis system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Velocity modulated capillary electrophoresis analysis system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-790959