VEGFR-3 inhibitor materials and methods

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C530S329000, C530S328000, C530S327000, C530S326000, C530S325000, C530S324000, C530S317000, C530S323000, C530S391100, C530S391700, C424S001570, C424S001690, C424S192100, C424S193100, C514S011400, C514S019300

Reexamination Certificate

active

07611711

ABSTRACT:
The present invention relates to the diagnosis, evaluation, and therapeutic intervention of disorders mediated by the activity of cell surface receptor VEGFR-3, which activity often is stimulated by VEGFR-3 ligands VEGF-C and VEGF-D. More particularly, the present invention identifies novel methods and compositions for the inhibition of VEGF-C/D binding to VEGFR-3. The compositions of the present invention will be useful in the inhibition of angiogenesis and lymphangiogenesis.

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