VEGF peptides and their use for inhibiting angiogenesis

Details VEGF peptides and their use for inhibiting angiogenesis VEGF peptides and their use for inhibiting angiogenesis

2007-05-29

2007-05-29

Landsman, Robert S. (Department: 1647)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C514S002600, C530S317000, C530S327000, C530S328000, C530S329000

Reexamination Certificate

active

10398616

ABSTRACT:
A peptide having part or all of the amino acid sequence QKRKRKKSRYKSWSVP (which is part of VEGF) has the ability to inhibit angiogenesis.

REFERENCES:
patent: 2004/0054143 (2004-03-01), Selwood et al.
patent: WO 99/40197 (1999-08-01), None
patent: WO 01/27136 (2001-04-01), None
Jouan, Valerie et al. (Aug. 1, 1999) “Inhibition ofIn vitroAngiogenesis by Platelet Factor-4-Derived Peptides and Mechanism of Action”Blood94(3):984-993.
Piosssek, Christine et al. (Feb. 26, 1999) “Vascular Endothelial Growth Factor (VEGF) Receptor II-Derived Peptides Inhibit VEGF”The Journal of Biological Chemistry274(9):5612-5619.
Soker, Shay et al. (Dec. 12, 1987) “Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165” Journal of Biological Chemistry272(50):31582-31588.
Bae, Dong-Goo, Gho, Yong-Song, Yoon, Wan-Hee, Chae, Chi-Bom “Arginine-rich Anti-vascular Endothelial Growth Factor Peptides Inhibit Tumor Growth and Metastasis by Blocking Angiogenesis,”The Journal of Biological Chemistry275(18): 13588-13596, May 5, 2000, published in the U.S.A.

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