VEGF gene transfer into endothelial cells for vascular prosthesi

Details VEGF gene transfer into endothelial cells for vascular prosthesi VEGF gene transfer into endothelial cells for vascular prosthesi

1996-05-15

1998-07-28

Chambers, Jasemine C.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 931, 424 932, 4351723, 435325, A01N 6300, C12N 1500

Patent

active

057859655

ABSTRACT:
Endothelial cells derived from subcutaneous adipose tissue are genetically modified to express the endothelial cell-specific angiogenic factor VEGF. The modified cells are sodded onto a vascular prosthesis for transplantation into an autologous or allogeneic recipient. The method accelerates endothelialization on the luminal surface of the vessel, and promotes collateral circulation in distal ischemic organs.

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