Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-02-02
2008-07-15
Saoud, Christine J (Department: 1647)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C424S134100, C424S192100, C435S071100, C435S252300, C435S320100, C435S325000, C435S358000, C514S002600, C514S012200, C530S350000, C530S387300, C536S023400
Reexamination Certificate
active
07399612
ABSTRACT:
Nucleic acid molecules encoding fusion proteins which bind and inhibit vascular endothelial growth factor (VEGF). The VEGF-binding fusion proteins are therapeutically useful for treating VEGF-associated conditions and diseases, and are specifically designed for local administration to specific organs, tissues, and/or cells.
REFERENCES:
patent: 5851999 (1998-12-01), Ullrich et al.
patent: 6011003 (2000-01-01), Charnock-Jonee
patent: 6270993 (2001-08-01), Shibuya
patent: 6897294 (2005-05-01), Davis-Smyth et al.
patent: WO 97/44453 (1997-11-01), None
patent: WO 98/13071 (1998-04-01), None
patent: WO 00/75319 (2000-12-01), None
Wells, J.A. (1990). Additivity of mutational effects in proteins. Biochemistry. 29(37):8509-8517.
Ngo et al. (1994). Computational complexity, protein structure prediction, and the Levinthal paradox. In Merz and Le Grand (Eds.) The Protein Folding Problem and Tertiary Structure Prediction. Birkhauser: Boston, pp. 491-495.
Skolnick et al. (2000). From genes to protein structure and function: novel applications of computational approaches in the genomic era. Trends in Biotechnology. 18:34-39.
Phillips, A.J. (2001). The challenge of gene therapy and DNA delivery. Journal of Pharmacy and Pharmacology. 53:1169-1174.
Palù et al. (1999). In pursuit of new developments for gene therapy. Journal of Biotechnology. 68:1-13.
Wang et al. (1999). Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acds Research. 27(23):4609-4618.
Kaufman et al. (1999). Transgenic analysis of a 100-kb human B-globulin cluster-containing DNA fragment propagated as a bacterial artificial chromosome. Blood. 94(9):3178-3184.
Wigley et al. (1994). Site-specific transgene insertion: an approach. Reprod. Fertil. Dev. 6:585-588.
Davis-Smyth et al. (1996). The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Fit-1 determines ligand binding and may initiate a signal transduction cascade. The EMBO Journal. 15(18):4919-4927.
Holash, J., et al., (2002) PNAS, 99(17):11393-11398.
Heidaran, M.A., et al., (1990) J. Biol. Chem. 265(31):18741-18744.
Cunningham, S.A., et al., (1997) Biochem. Biophys. Res. Comm. 231:596-599.
Fuh, G., et al., (1998) J. Biol. Chem. 273(18):11197-11204.
Wiesmann, C., et al., (1997) Cell, 91:695-704.
Barleon, B., et al., (1997) J. Biol. Chem. 272(16):10382-10388.
Davis-Smyth, T., et al., (1998) J. Biol. Chem. 273(6):3216-3222.
Wulff, C., etal., (2002) Endocrinology 143(7):2797-2807.
Daly Thomas J.
Fandl James P.
Papadopoulos Nicholas J.
Gregg, Esq. Valeta
Lockard Jon M
Regeneron Pharmaceuticals Inc.
Saoud Christine J
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