Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2008-07-22
2008-07-22
Burkhart, Michael (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C424S093200, C424S211100
Reexamination Certificate
active
10513094
ABSTRACT:
The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein ofparamyxovirusis modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo.
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Hasegawa Mamoru
Iida Akihiro
Inoue Makoto
Kinoh Hiroaki
Kobayashi Masanori
Burkhart Michael
Clark & Elbing LLP
DNAVEC Research Inc.
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