Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Rodent cell – per se
Patent
1995-02-06
2000-04-18
Guzo, David
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Rodent cell, per se
4353201, C12N 510, C12N 1585
Patent
active
060514264
ABSTRACT:
The invention concerns a composition useful for the manufacture of vaccines containing particles having the immunogenic properties characteristic of the antigen HBsAg, these particles being more particularly characterized by the fact that the particles equally contain a receptor for polymerized human albumin. They are obtained by transformation of human or animal cells by a vector containing a DNA sequence coding for the S and pre-S regions of a genome of viral hepatitis B, this DNA sequence being placed under the direct control of a promoter permitting the effective transcription of the sequence in the human or animal cells transformable by the vector.
REFERENCES:
patent: 4113712 (1978-09-01), Funakoshi
patent: 4118478 (1978-10-01), Prince
patent: 4428941 (1984-01-01), Galibert et al.
patent: 4554157 (1985-11-01), Skelly et al.
patent: 4722840 (1988-02-01), Valenzuela et al.
patent: 5024938 (1991-06-01), Nozaki et al.
patent: 5098704 (1992-03-01), Valenzuela
patent: 5670530 (1997-09-01), Thill
Christman et al., "Amplification of Expression of Hepatitis B Surface Antigen in 3T3 Cells Cotransfected with a Dominant-Acting Gene and Cloned Viral DNA", PNAS, vol. 79, pp. 1815-1819, Mar. 1982.
Kaufman et al., "Amplification and Expression of Sequences Cotransfected with a Modular Dihydrofolate Reductase Complementary DNA Gene," J. Mol. Biol., vol. 159, pp. 601-621, 1982.
Subramani et al., "Analysis of Gene Expression Using Simian Virus 40 Vectors", Anal. Biochem., vol. 135, pp. 1-15, 1983.
Chakrabaotz et al. "Identification of Integrated Hepatitis B Virus DNA and Expression of Viral RNA in an HBsAg-Producing Human Hepatocellular Carcinoma Cell Line", Nature, vol. 286 Jul. 31, 1980, pp. 531-533.
Malpiece et al. "The Gene S Promoter of Hepatitis B Virus Confers Constitutive Gene Expression", Nucleic Acids Res., vol. 11, No. 13, 1983, pp. 4645-4654.
Pourcel et al. "Transcription of the Hepatitis B Surface Antigen Gene in Mouse Cells Transformed with Cloned Viral DNA", J. of Virol., Apr. 1982, vol. 42, No. 1, pp. 100-105.
Edman et al. "Integration of Hepatitis B Virus Sequences and Their Expression in a Human Hepatoma Cell", Nature, vol. 286, Jul. 31, 1980, pp. 535-538.
Alberti et al., "Virus Receptors for Polymerized Human Serum Albumin and Antireceptor Antibody in Hepatitis B Virus Infection," Prog. Clin. Biol. Res., 143: 327-336 (1983).
Mitsunobu et al., "A Receptor for Polymerized Human and Chimpanzee Albumins on Hepatitis B Virus Particles Co-occurring with HBeAg," Gastroeneterology, 76(2): 242-247 (1979).
Jacobs et al., "Simultaneous Synthesis and Assembly of Various Hepatitis B Surface Proteins in Saccharomyuces cerevisiae," Gene, 80: 279-291 (1989).
Lenkei et al., "Receptors for Polymerized Albumin on Liver Cells," Experientia, 33/8: 1046-1047 (1977).
Machida et al., "A Hepatitis B Surface Antigen Polypeptide (P31) With the Receptor for Polymerized Human as Well as Chimpanzee Albumins," Gastroenterology, 85(2): 268-274 (1983).
Michel et al., "Synthesis in Animal Cells of Hepatitis B Surface Antigen Particles Carrying a Receptor for Polymerized Human Serum Albumin," Proc. Natl. Acad. Sci. (USA), 81: 7708-7712 (1984).
Milich et al., "Characterization of the Interaction Between Polymerized Human Albumin and Hepatitis B Surface Antigen," Gastroenterology, 81(2): 218-225 (1981).
Ringold et al., "Co-Expression and Amplification of Dihydrofolate Reductase cDNA and the Escherichia coli XGPRT Gene in Chinese Hamster Ovary Cells," J. Mol. Appl. Genet., 1: 165-175 (1981).
Stibbe et al., "Variable Protein Composition of Hepatitis B Surface Antigen from Different Donors," Virology, 123: 436-442 (1982).
Stratowa et al., "Recombinant Retroviral DNA Yielding High Expression of Hepatitis B Surface Antigen," EMBO J., 1(12): 1573-1578 (1982).
Wang et al., "Enhanced Production of Hepatitis B Surface Antigen in NIH 3T3 Mouse Fibroblasts by Using Extrachromosomally Replicating Bovine Papillomavirus Vector," Mol. Cell. Biol., 3(6): 1032-1039 (1983).
Mitsunobu et al., "A Receptor for Polymerized Human and Chimpanzee Albumins on Hepatitis B Virus Particles Co-occurring with HBeAg," Biol. Abstr., 68: 3690 (1979).
Machida et al., "A Hepatitis B Surface Antigen Polypeptide (P31) With the Receptor for Polymerized Human as Well as Chimpanzee Albumins," Biol. Abstr., 77: 12366 (1984).
Milich et al., "Characterization of the Interaction Between Polymerized Human Albumin and Hepatitis B Surface Antigen," Chem. Abstr., 95: 113155 (1981).
Alberti et al., "Virus Receptors for Polymerized Human Serum Albumin and Antireceptor Antibody in Hepatitis B Virus Infection," Chem. Abstr., 100: 172783 (1984).
Burnette, et al., "Properties and Relative Immunogenicity of Various Preparations of Recombinant DNA-derived Hepatitis B Surface Antigen," Chem. Abstr., 103: 121281w.
Malpiece, deceased Yves
Michel Marie-Louise
Sobczak Elaine
Streeck Rolf E.
Tiollais Pierre
Guzo David
Institut Pasteur, Institut National de la Sante et de la Recherc
LandOfFree
Vectors for transforming CHO cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Vectors for transforming CHO cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vectors for transforming CHO cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2335539