Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1995-03-20
1998-10-13
Guzo, David
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 914, 4352542, 536 23, C12P 2102, C12P 1934, C12N 119, C12N 1515
Patent
active
058210792
ABSTRACT:
Functional block of DNA enabling to prepare hirudine from yeast, characterized in that it comprises at least:--the gene of hirudine or one of its variants (gene H); --A DNA sequence (S.sub.tr) comprising the signals providing for the transcription of the gene H by the yeast.
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Woods et al J. Clin. Invest. vol. 74 pp. 634-638 (1984).
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Suggs et al (1981) PNAS 78: 6613-6617.
Bitter et al (1984) PNAS 81: 5330-5334.
Brake, et al (1984) PNAS 81: 4642-4646.
Chemical Abstracts, vol. 100, No. 19, 7 May, 1984; p. 227, ref. No. 152937g, Columbus, Hoio, US; J Dodt, et al The Complete Amino Acid Sequence of Hirudin, a Thrombin Specific Inhibitor. Application of Color Caboxymethylation--& Febs Lett. 1984 165(2), 180-4.
LeCocq Jean-Pierre
Lemoine Yves
Loison Gerard
Tolstoshev Paul
Guzo David
Sandals William
Transgene S.A.
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